In this paper, we present a novel quantitative description of intracellular and t-tubular Ca2+ dynamics in a model of rat cardiac ventricular myocyte. In order to simulate recently published data, the model incorporates t-tubular and peripheral dyads and intracellular subspaces, segmentation of the t-tubular luminal volume, reformulation of the inactivation properties of t-tubular land peripheral L-type calcium current (ICa) and a description of exogenous Ca2q+ buffer function in the intracellular space. The model is used to explore activity-induced changes of ion concentration in the intracellular and t-tubular spaces and their role in excitation - contraction coupling in ventricular myocytes. and Obsahuje Appendix se seznamy literatury, užitých zkratek a symbolů
The methodology of modelling and of qualitative analysis of large rotating systems with gear and bearing couplings is presented. The emphasis is laid on the modelling of nonlinear gear and bearing couplings and on their influence on the dynamic system response to the internal kinematic excitation in gearing and to parametric excitation caused by the time-varying meshing stiffness. The aim is to introduce a method of investigation the beahviour of the rotating system influenced by the mentioned excitation and to examine the influence of chosen operational parameters. The methodology of modelling and of qualitative dynamic behaviour analysis is tested on a two-stage gearbox. and Obsahuje seznam literatury