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Start Over Coverage 265-274

1. Laplace equation in the half-space with a nonhomogeneous Dirichlet boundary condition

Creator:
Amrouche, Cherif and Nečasová, Šárka
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
the Laplace equation, weighted Sobolev spaces, the half space, existence, uniqueness, and regularity
Language:
English
Description:
We deal with the Laplace equation in the half space. The use of a special family of weigted Sobolev spaces as a framework is at the heart of our approach. A complete class of existence, uniqueness and regularity results is obtained for inhomogeneous Dirichlet problem.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

2. Metronidazole attenuates the intensity of inflammation in experimental autoimmune uveitis

Creator:
Seidler Stangova, P., Dusek, O. , Klimova, A., Heissigerova, J., Kucera, T. , and Svozilkova, P.
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
experimental autoimmune uveitis, uveitis, antibiotics, microbiome, metronidazole, and ciprofloxacin
Language:
English
Description:
Autoimmune uveitis is a serious sightthreatening disease that in many cases fails to respond to conventional immunosuppressive or biological therapy. Experimental models used in research allow more detailed study of pathogenesis of the autoimmune process and testing new therapeutic strategies. Recent results show that infection can trigger autoimmune diseases, and some commensal microorganisms are essential in causing disease activity. The aim of this work was to assess the effect of broadspectrum antibiotics – combination of metronidazole and ciprofloxacin or metronidazole alone – on the intensity of intraocular inflammation in experimental autoimmune uveitis (EAU). EAU was induced in mouse strain C57BL/6J by interphotoreceptor retinoid-binding protein in complete Freund’s adjuvant and pertussis toxin. The grade of uveitis was assessed clinically and histologically in haematoxylin and eosin-stained tissues. Lymphocytes and macrophages were detected in cryosections using the immunoperoxidase method with antibodies. The therapy was commenced one week before EAU induction and continued throughout the experiment. In addition, metronidazole treatment was also started two weeks before EAU induction. Antibiotics significantly reduced the intensity of uveitis compared to the control group (P < 0.05). The effects of combination of ciprofloxacin and metronidazole and of metronidazole alone were similar when the therapy started one week before EAU induction (P < 0.05). Metronidazole commenced two weeks before EAU induction and throughout the experiment suppressed the intensity of EAU with even higher statistical significance (P < 0.0001). It can be assumed that the high protective effect of metronidazole on EAU intensity may be due not only to its antimicrobial effect, but also to its immunomodulatory activity
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3. The phycobilisome terminal emitter transfers its energy with a rate of (20 ps)-1 to photosystem II

Creator:
Acuña, A. M., Van Alphen, P., Grondelle, Rienk Van, and Van Stokkum, I. H. M.
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
biofyzika, biophysics, target analysis, excitation energy transfer, global analysis, light harvesting, 2, and 581
Language:
Multiple languages
Description:
Ultrafast time resolved emission spectra were measured in whole cells of a PSI-deficient mutant of Synechocystis sp. PCC 6803 at room temperature and at 77K to study excitation energy transfer and trapping. By means of a target analysis it was estimated that the terminal emitter of the phycobilisome, termed allophycocyanin 680, transfers its energy with a rate of (20 ps)-1 to PSII. This is faster than the intraphycobilisome energy transfer rates between a rod and a core cylinder, or between the core cylinders., A. M. Acuña, P. Van Alphen, R. Van Grondelle, I. H. M. Van Stokkum., and Obsahuje bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public