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Start Over Contributor Laco, Jan , 1979- Date 2012

1. Case 1-2012: ANCA associated glomerulonephritis in combination with IgG4 Positive mediastinal mass in a patient with ankylosing spondylitis treated with TNF alpha inhibitors

Creator:
Tošovský, Marian, Bradna, Petr, Laco, Jan, Podhola, Miroslav, Soukup, Tomáš, Brožík, Jan, and Šteiner, Ivo
Format:
braille, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, statistics, kongresy jako téma, práce podpořená grantem, and TEXT
Subject:
protilátky proti cytoplazmě neutrofilů--krev, monoklonální protilátky humanizované--terapeutické užití, fokálně segmentální glomeruloskleróza--diagnóza--imunologie--komplikace, lidé, imunoglobulin G--krev, mužské pohlaví, nemoci mediastina--diagnóza--imunologie--komplikace, lidé středního věku, ankylózující spondylitida--farmakoterapie--komplikace, and TNF-alfa--antagonisté a inhibitory
Language:
English
Description:
Professor Ivo Šteiner, MD, PhD - editor, Marian Tošovský, Petr Bradna, Jan Laco, Miroslav Podhola, Tomáš Soukup, Jan Brožík and Literatura 15
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

2. Expression of matrix metalloproteinase 9 in patients with Oral Lichen planus

Creator:
Paulusová, Vladimíra, Laco, Jan, Dřízhal, Ivo, and Slezák, Radovan
Format:
braille, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, statistics, práce podpořená grantem, and TEXT
Subject:
fibrom--metabolismus--patologie, lidé, lichen planus orální--metabolismus--patologie, matrixová metaloproteinasa 9--metabolismus, ústní sliznice--metabolismus--patologie, and nádory úst--metabolismus--patologie
Language:
English
Description:
Introduction: Oral Lichen planus (OLP) is chronic inflammatory oral mucosal disease of unknown etiology. Basement membrane damage and T‑cell migration in OLP may be mediated by matrix metalloproteinases (MMPs). We examined the expression of matrix metalloproteinase 9 to support this hypothesis. Materials and methods: The study population consisted of 71 patients with OLP and 10 control patients with oral fibromas. Indirect immunohistochemistry was used for detection of MMP 9 expression (polyclonal rabbit anti‑human MMP antibody). Results: In all cases of OLP, the MMP‑9 expression was seen mainly in the area of lymphocytic inflammatory infiltrate in the lamina propria including lymphocytes within the overlying epithelium. In addition, it was observed in the epithelial keratinocytes, particularly in the stratum basale and stratum spinosum with occasional positivity in the superficial layer. Fibroblasts and endothelium of small vessels in the lamina propria showed MMP9 expression as well. In all cases of oral mucosal fibromas, the MMP‑9 expression was seen only in fibroblasts and in endothelium of small vessels with occasional positivity within the overlying epithelium. It remains unclear, whether MMP‑9 is directly connected to OLP pathogenesis., Vladimíra Paulusová, Jan Laco, Ivo Dřízhal, Radovan Slezák, and Literatura 24
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public