Value of the oxygen pulse curve for the diagnosis of coronary artery disease

Title:

Value of the oxygen pulse curve for the diagnosis of coronary artery disease

Creator:

De Lorenzo, A, Da Silva, C. L, Castro Souza, F. C, and Souza Leão Lima, R. De

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:fe87060a-7404-42ff-a29f-2cac0d3735e8
uuid:fe87060a-7404-42ff-a29f-2cac0d3735e8
issn:0862-8408

Subject:

fyziologie, physiology, cardiopulmonary exercise testing, oxygen pulse, myocardial perfusion scintigraphy, myocardial ischemia, coronary artery disease, diagnosis, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

This study investigated the value of oxygen (O2) pulse curves obtained during cardiopulmonary exercise testing (CPET) for the diagnosis of coronary artery disease (CAD). Forty patients with known coronary anatomy (35.0 % normal, 27.0 % single-vessel and 38.0 % multivessel CAD) underwent CPET with radiotracer injection at peak exercise, followed by myocardial scintigraphy. O2 pulse curves were classified as: A-normal, B-probably normal (normal slope with low peak value); C-probably abnormal (flat, with low peak value); or D- definitely abnormal (descending slope). Sensitivity, specificity, positive and negative predictive values of the O2 pulse curve pattern (A or B vs. C or D) for the diagnosis of CAD were, respectively, 38.5 %, 81.3 %, 76.9 %, and 44.8 %. The concordance rate between the abnormal O2 pulse curve pattern and ischemia in myocardial scintigraphy was 38.1 %. Age and the extent of scintigraphic perfusion defect, but not the abnormal O2 pulse curve patterns (B or C or both combined) were independently associated with CAD. In conclusion, the O2 pulse curve pattern has low diagnostic performance for the diagnosis of obstructive CAD, and the abnormal curve pattern was not associated with myocardial ischemia defined by scintigraphy., A. De Lorenzo, C. L. Da Silva, F. C. Castro Souza, R. De Souza Leão Lima., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:5

Harvested from:

CDK

Metadata only:

false