Heart rate variability and inflammatory response in rats with lipopolysaccharide-induced endotoxemia

Title:

Heart rate variability and inflammatory response in rats with lipopolysaccharide-induced endotoxemia

Creator:

Ivan Žila, Daniela Mokrá, Kopincova, J., Kolomaznik, M., Michal Javorka, and Andrea Čalkovská

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:fce106f4-048a-4eb3-b435-e97499703326
uuid:fce106f4-048a-4eb3-b435-e97499703326
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, srdeční rytmus, autonomní nervový systém, heart rate, autonomic nervous system, heart rate variability, interleukin 6, lipopolysaccharide, endotoxemia, rat model, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aim of the study was to evaluate short-term heart rate variability (HRV) as an index of cardiac autonomic control in rats with lipopolysaccharide (LPS)-induced endotoxemia. Animals were injected intraperitoneally with LPS (100 μg/kg b.w.) and control group with an equivalent volume of saline. ECG recordings were done before (base) and 60, 120, 180, 240 and 300 min after LPS or saline administration. HRV magnitude was quantified by time and frequency-domain analysis (mean RR interval, SDRR, RMSSD, spectral powers in low (LF) and high frequency (HF) bands. Heart tissue homogenates and plasma were analyzed to determine interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α) and oxidative stress level (TBARS). Administration of lipopolysaccharide was followed by continuous rise in colonic body temperature compared to saline-treated controls. Endotoxemia in rats was accompanied by significant decrease in HRV spectral activity in high-frequency range at maximal body temperature (logHFpower: 1.2±0.5 vs. 1.9± 0.6 ms2, P<0.01). Increased IL-6 was found in heart tissue homogenates of LPS rats (8.0±0.6 vs. 26.4±4.8 pg/ml, (P<0.05). In conclusions, reduced HRV in HF band may indicate a decreased parasympathetic activity in LPS-induced endotoxemia as basic characteristics of altered cardiac control during response to endotoxemia., I. Zila, D. Mokra, J. Kopincova, M. Kolomaznik, M. Javorka, A. Calkovska., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:Suppl 5

Harvested from:

CDK

Metadata only:

false