Changes of Dopamine-Beta-Hydroxylase Activity During Ontogenesis in Healthy Subjects and in an Experimental Model (Rats)

Title:

Changes of Dopamine-Beta-Hydroxylase Activity During Ontogenesis in Healthy Subjects and in an Experimental Model (Rats)

Creator:

Paclt, I. and Koudelová, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:fca4838e-55b8-4583-bbb6-5d5ba66d8a2b
uuid:fca4838e-55b8-4583-bbb6-5d5ba66d8a2b

Subject:

Dopamine-beta-hydroxylase (DBH), Rats, Human, Serum, Developmental changes, and Noradrenergic system

Type:

article, model:article, and TEXT

Description:

In children and adolescents (250 healthy subjects) serum dopamine-beta-hydroxylase (DBH) activity (23.95.2 to 57.117.5 μmol/min/ml) increases with the age between 3-10 years, later it decreases approximately by the age of 10-14 years. At the age of 21 to 60 years DBH level is stable. Our study described decreasing DBH activity in adolescents at the age of 10-14 years in the studied sample of healthy persons. Experimental animals (200 Wistar rats, 5-120 days old) show the same trend of enzymatic activity, similarly as in humans. DBH activity in rats is between 0.850.1 to 2.80.05 μmol/min/ml. This activity is highest in 5-day-old rats; it decreases till the age of 14 days and increases mainly in 14- to 35-day-old animals. Decrease of DBH activity in rats between 35 to 40 days is significant and corresponds to the reduction of DBH activity in adolescent humans (10-14 years). Adult rats (aged 90-120 days) show a stable DBH activity. DBH activity intermediately decreases in 10- to 14-year-old children. This decrease corresponds to the intermediate developmental changes of electrophysiological parameters (decreasing EEG activity in healthy adolescents occurs in 10-14 years old children). Puberty is coupled with intermediate decreasing of DBH activity in man and also in experimental animals in the period of prominent psychological and physiological changes.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2004 Volume:53 | Number:6

Harvested from:

CDK

Metadata only:

false