Lipofuscin-like pigments in the rat heart during early postnatal development: effect of selenium supplementation

Title:

Lipofuscin-like pigments in the rat heart during early postnatal development: effect of selenium supplementation

Creator:

Ivana Ošťádalová, Zuzana Charvátová, and Jiří Wilhelm

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:fc6d0558-37a7-4a67-9523-b7b98c20546e
uuid:fc6d0558-37a7-4a67-9523-b7b98c20546e
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, srdce, selen, heart, selenium, early postnatal development, lipofuscin-like pigment, radical oxygen species, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aim of the study was to char acterize a) the lipofuscin-like pigment (LFP) accumulation (an indicator of ROS production) in the rat heart during early postnatal period and b) possible antioxidative role of selenium. Experimental animals received Na 2 SeO 3 in drinking water during gravidity and up to day 15 post partum . Two fluorophores of LFP in the hearts of 1-, 4-, 7- and 15-day-old rats were evaluated by fluorescent analysis. The highest level of heart/body weight ratio in control rats was observed on day 4, in the Se-supplemented rats on day 7. Cardiac LFP content in controls increased from postnatal day 4, in the hearts of Se-supplemented rats the LFP content increased already from day 1. As compared with the Se-supplemented group the LFP content of control hearts was significantly higher on day 1 but significantly lower on day 4. LFP concentration in control hearts decreased from postnatal day 1 to 4; this decrease was followed by significant increa se until day 7 and decrease to day 15. LFP concentration in the Se-supplemented hearts was the highest on postnatal day 7; it differed from controls on day 1 and 4. Significant changes of LF P suggest an important role of ROS during critical ontogenetic period., I. Ošťádalová, Z. Charvátová, J. Wilhelm., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:6

Harvested from:

CDK

Metadata only:

false