Acute toxicities of 2-dialkylaminoalkyl-(dialkylamido)-fluoro-phosphates

Title:

Acute toxicities of 2-dialkylaminoalkyl-(dialkylamido)-fluoro-phosphates

Creator:

Bajgar, J., Fusek, J., Hrdina, V., Patočka, J., and Vachek, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:fba709a2-3332-4a8b-97b7-6d4f7a6b496d
uuid:fba709a2-3332-4a8b-97b7-6d4f7a6b496d

Subject:

LD50 values and 2-dialkylaminoalkyl-(dialkylamido)-fluorophosphates

Type:

article, model:article, and TEXT

Description:

Toxicities expressed as LD50 values of 2-dialkylaminoalkyl-(dialkylamido)-fluorophosphates for rats and mice (i.m. administration) were determined. Rats were more sensitive to these compounds than mice: LD50 values varied from 17 (rats) to 1222 (mice) ^g/kg. LD50 values at different routes of administration (i.v., i.m., s.c., p.o. and p.c.) for one derivative of this group, 2-dimethylaminoethyl-(dimethyIamido)- fluorophosphate, were determined. Depending on the route of administration, LD50 values varied from 11 (i.v.) to 190 (p.o.) pg/V.g for rats and from 27.6 (i.v.) to 222 (p o.)/rg/kg for mice, respectively. Percutaneous toxicity in rats only (LD50 = 1366//g/kg) was determined.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1992 Volume:41 | Number:5

Harvested from:

CDK

Metadata only:

false