Hypoxia-induced LXRα contributes to the migration and invasion of gastric cancer cells

Title:

Hypoxia-induced LXRα contributes to the migration and invasion of gastric cancer cells

Creator:

Guo, R. and Yang, Bin

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f8497ef1-9b8c-457c-9393-cb7a060e221e
uuid:f8497ef1-9b8c-457c-9393-cb7a060e221e

Subject:

hypoxia, HIF-1α, LXRα, gastric cancer, and prognosis

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Gastric cancer is characterized by the presence of high invasion ability, hypoxia and chemoresistance. Previous studies reported that liver X receptor α (LXRα) was involved in epithelial-mesenchymal transition (EMT) of gastric cancer cells. However, hypoxia-mediated EMT and the role of LXRα in gastric cancer remained elusive. In this study, we demonstrated that LXRa mRNA and protein levels were up-regulated by hypoxia treatment and LXRα played an important role in HIF-1 dimer induced-EMT. The putative HIF-1α binding site was identified in the LXRa promoter. Expression of LXRα and HIF-1α was significantly up-regulated in gastric cancer tissues compared to that in normal tissues. More importantly, we noticed that the expression of LXRα and HIF-1α was significantly correlated. Taken together, these data suggested that LXRα is regulated by the activity and accumulation of HIF-1α and contributes to EMT of gastric cancer cells. This suggests that targeting LXRα might be a potential approach for improving survival of gastric cancer patients.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

91-101

Source:

Folia biologica | 2021 Volume:67 | Number:3

Harvested from:

CDK

Metadata only:

false