Ventricular assist devices in heart failure: how to support the heart but prevent atrophy?

Title:

Ventricular assist devices in heart failure: how to support the heart but prevent atrophy?

Creator:

Miloš Pokorný, Luděk Červenka, Ivan Netuka, Jan Pirk, Koňařík, M., and Jan Malý

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f533b4a4-16a6-4e49-a244-a8584de87b61
uuid:f533b4a4-16a6-4e49-a244-a8584de87b61

Subject:

Fyziologie člověka a srovnávací fyziologie, srdce, heart, ventricular assist devices, cardiac, atrophy, mechanical unloading, clenbuterol, experimental models, heterotopic heart transplantation, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Ventricular assist devices (VAD ) have recently established themselves as an irreplaceable th erapeutic modality of terminal heart failure. Because of the worldwide shortage of donors, ventricular assist devices play a key role in modern heart failure therapy. Some clinical data have revealed the possibility of cardiac recovery during VAD applic ation. On the other hand, both clinical and experiment al studies indicate the risk of the cardiac atrophy development, especially after prolonged mechanical unloading. Little is known about the specific mechanisms governing the unloading-induced cardiac atrophy and about the exact ultrastructural changes in cardiomyocytes, and even less is known about the ways in which possible therapeutical interventions may affect heart at rophy. One aim of this review was to present important aspects of the development of VAD- related cardiac atrophy in humans and we also review the most significant observations linking clinical data and those derived from studies using experimental mo dels. The focus of this article was to review current methods applied to alleviate cardiac atrophy which follows mechanical unloading of the heart. Out of many pharmacological agents studied, only the selective beta2 agonist clenbuterol has been proved to have a significantly beneficial effect on unloading-induced atrophy. Mechanical means of atrophy alleviation also seem to be effective and promising., M. Pokorný ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:2

Harvested from:

CDK

Metadata only:

false