Chronic cigarette smoking alters circulating sex hormones and neuroactive steroids in premenopausal women

Title:

Chronic cigarette smoking alters circulating sex hormones and neuroactive steroids in premenopausal women

Creator:

Michaela Dušková, Kateřina Šimůnková, Hill, M., Velíková, M., Kubátová, J., Lyudmila Kantcheva, Hana Kazihnitková, Hruškovičová, H., Pospíšilová, H., Rácz, B., Salátová, M., Veronika Cirmanová, Eva Králíková, Luboslav Stárka, and Antonín Pařízek

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f28b8324-3c52-4976-9b89-e98ae1e47529
uuid:f28b8324-3c52-4976-9b89-e98ae1e47529

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, smoking, menstrual cycle, luteal phase, follicular phase, sex hormones, neuroactive steroids, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

a1_Chronic smoking alters the circulating levels of sex hormones and possibly also the neuroactive steroids. However, the data available is limited. Therefore, a broad spectrum of free and conjugated steroids and related substances was quantified by GC-MS and RIA in premenopausal smokers and in age-matched (38.9±7.3 years of age) non-smokers in the follicular (FP) and luteal phases (LP) of menstrual cycle (10 non-smokers and 10 smokers, in the FP, and 10 non-smokers and 8 smokers in the LP). Smokers in both phases of the menstrual cycle showed higher levels of conjugated 17-hydroxypregnenolone, 5α-dihydroprogesterone, conjugated isopregnanolone, conjugated 5α-pregnane-3β,20α-diol, conjugated androstenediol, androstenedione, testosterone, free testosterone, conjugated 5α-androstane-3α/β,17β-diols, and higher free testosterone index. In the FP, the smokers exhibited higher levels of conjugated pregnenolone, progesterone, conjugated pregnanolone, lutropin, and a higher lutropin/follitropin ratio, but lower levels of cortisol, allopregnanolone, and pregnanolone. In the LP, the smokers exhibited higher levels of free and conjugated 20α-dihydropregnenolone, free and conjugated dehydroepiandrosterone, free androstenediol, 5α-dihydrotestosterone, free and conjugated androsterone, free and conjugated epiandrosterone, free and conjugated etiocholanolone, 7α/β-hydroxy-dehydroepiandrosterone isomers, and follitropin but lower levels of estradiol and sex hormone binding globulin (SHBG) and lower values of the lutropin/follitropin ratio. In conclusion, chronic cigarette smoking augments serum androgens and their 5α/β-reduced metabolites (including GABAergic substances) but suppresses the levels of estradiol in the LP and SHBG and may induce hyperandrogenism in female smokers., a2_The female smokers had pronouncedly increased serum progestogens but paradoxically suppressed levels of their GABA-ergic metabolites. Further investigation is needed concerning these effects., M. Dušková ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:1

Harvested from:

CDK

Metadata only:

false