Low seroprevalence and low incidence of infection with Toxoplasma gondii (Nicolle et Manceaux, 1908) in pediatric hematopoietic cell transplantation donors and recipients: Polish nationwide study

Title:

Low seroprevalence and low incidence of infection with Toxoplasma gondii (Nicolle et Manceaux, 1908) in pediatric hematopoietic cell transplantation donors and recipients: Polish nationwide study

Creator:

Czyzewski, Krzysztof , Fraczkiewicz, Jowita , Salamonowicz, Malgorzata , Pieczonka, Anna , Zajac-Spychala, Olga , Zaucha-Prazmo, Agnieszka , Gozdzik, Jolanta , and Styczynski, Jan

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f2788070-dfb9-44e0-9b0a-138e081b6874
uuid:f2788070-dfb9-44e0-9b0a-138e081b6874
doi:10.14411/fp.2019.019

Subject:

bone marrow transplantation, children, prophylaxis, toxoplasmosis, treatment, trimethoprime, and sulfamethoxazole

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Toxoplasmosis is a potentially fatal complication after hematopoietic cell transplantation (HCT). Pre-transplant seropositivity of graft recipient to Toxoplasma gondii (Nicolle et Manceaux, 1908) is an important factor for disease reactivation after HCT. As toxoplasmosis epidemiology varies all over the world, we performed a Polish nationwide retrospective cohort study to determine the seroprevalence of toxoplasmosis in donors and pediatric allogeneic and autologous HCT recipients and the incidence of clinically evident toxoplasmosis in this patient group. Polish adult donors had higher anti-T. gondii seroprevalence than Polish pediatric donors (28% vs 8%; OR = 4.4; p = 0.02) and allo-HCT recipients (28% vs 17%; OR = 1.9; p = 0.01). Clinically apparent disease occurred in 1% of allo-HCT recipients: it was diagnosed by PCR as cerebral and/or ocular toxoplasmosis and successfully treated with antiprotozoal therapy. Regarding current practice, no prospective screening for infection of T. gondii in pediatric HCT centres is being performed, but, vast majority of HCT pediatric patients are receiving anti-T. gondii active prophylaxis. Since pre-HCT T. gondii serology was not assessed in all HCT; recipients, we propose this test should be a standard practice. Standardisation of management with infection of T. gondii in children after HCT is needed.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

1-6

Source:

Folia parasitologica | 2019 Volume:66 | Number:1

Harvested from:

CDK

Metadata only:

false