Long-lasting anticryptosporidial activity of nitazoxanide in an immunosuppressed rat model

Title:

Long-lasting anticryptosporidial activity of nitazoxanide in an immunosuppressed rat model

Creator:

Li, Xunde, Brasseur, Philippe, Agnamey, Patrice, Leméteil, Denis, Favennec, Loïc, Ballet, Jean-Jacques, and Rossignol, Jean-François

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f1e934e7-0cb3-48ab-95ef-3c8c7415111a
uuid:f1e934e7-0cb3-48ab-95ef-3c8c7415111a
doi:10.14411/fp.2003.003

Subject:

Cryptosporidium parvum, nitazoxanide, and immunosuppressed rat model

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Cryptosporidium parvum, Tyzzer, 1912 is identified as a common cause of diarrhoea in immunocompetent individuals. In immunocompromised, especially HIV-infected subjects, cryptosporidiosis causes severe chronic diarrhoea. In this study, nitazoxanide (NTZ) was compared for curative activity with sinefungin (SNF) and paromomycin (PRM) in immunosuppressed rats, a screening model for anticryptosporidial agents. NTZ at either 50 mg/kg/day, 100 mg/kg/day or 200 mg/kg/day resulted in seven days in a dose-dependent inhibition of oocyst shedding similar to that obtained with SNF (10 mg/kg/day) and PRM (100 mg/kg/day). Further discontinuation of SNF or PRM 100 mg/kg/day therapy resulted in early relapse of oocyst shedding which reached the pre-treatment levels in 2-4 days. In contrast, seven days after discontinuation of therapy, shedding inhibition was unchanged in NTZ-treated rats. Data prompt further assessment of the activity of NTZ on sequestered C. parvum.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

19-22

Source:

Folia parasitologica | 2003 Volume:50 | Number:1

Harvested from:

CDK

Metadata only:

false