Association between latent toxoplasmosis and clinical course of schizophrenia - continuous course of the disease is characteristic for Toxoplasma gondii-infected patients

Title:

Association between latent toxoplasmosis and clinical course of schizophrenia - continuous course of the disease is characteristic for Toxoplasma gondii-infected patients

Creator:

Çelik, Tuncay, Kartalci, Şükrü, Aytaş, Özgür, Akarsu, Gülay Aral, Gözükara, Harika, and Ünal, Süheyla

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f1b2b2df-cdc3-45bd-a67f-8400ad669ead
uuid:f1b2b2df-cdc3-45bd-a67f-8400ad669ead
issn:1803-6465
doi:10.14411/fp.2015.015

Subject:

toxoplazmóza, schizofreničtí pacienti, sérologie, toxoplasmosis, schizophrenic patients, serology, prognosis, 2, and 59

Type:

model:article and TEXT

Format:

electronic, počítač, and online zdroj

Description:

The aim of the present study was to investigate the association between various clinical aspects of schizophrenia and seropositivity against Toxoplasma gondii (Nicolle et Manceaux, 1908). We selected 94 patients with schizophrenia and investigated the seropositivity rate for anti-T. gondii IgG antibodies by ELISA. Clinical parameters of schizophrenic patients such as illness type and status, clinical course, awareness of the illness and need for electroconvulsive therapy (ECT) were compared with their serological status. Anti-T. gondii IgG antibodies were detected in 43 (46%) of schizophrenic patients. Chronic patients had a rate of 34 (72%) seropositivity, whereas 9 (22%) of the patients with partial remission showed evidence of latent toxoplasmosis. Of continuous patients, 35 (81%) were found to be seropositive and this rate was significantly more than in the other groups. The rate of latent toxoplasmosis was detected significantly higher in patients who lack awareness of schizophrenia (36, i.e. 72%) than the patients who were aware of their illnesses (7, i.e. 16%). Anti-T. gondii IgG antibodies were detected in 38 (70%) of ECT performed patients while this percentage was 13% in the ones who had never been treated with ECT. This difference was also statistically significant. We showed that Toxoplasma-infected subjects had 15× higher probability of having continuous course of disease than Toxoplasma-free subjects. Our results put forth the possibility of latent toxoplasmosis to have a negative impact on the course of schizophrenia and treatment response of schizophrenic patients., Tuncay Çelik, Şükrü Kartalci, Özgür Aytaş, Gülay Aral Akarsu, Harika Gözükara, Süheyla Ünal., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

1-6

Source:

Folia parasitologica | 2015 Volume:62 | Number:1

Harvested from:

CDK

Metadata only:

false