Androgens in SARS-CoV-2 coronavirus infections

Title:

Androgens in SARS-CoV-2 coronavirus infections

Creator:

Stárka, Luboslav and Dušková, Michaela

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e76d5d56-87a5-4e64-8aa1-b62b7a368596
uuid:e76d5d56-87a5-4e64-8aa1-b62b7a368596
doi:10.33549/physiolres.934724

Subject:

COVID-19, androgens, adrenal androgens, and male fertility

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Recent molecular biology findings have shown that for the penetration of the SARS-CoV-2 coronavirus into host cells, a key role is played by protease serine 2, the activity of which is dependent on androgens. The important role of androgens is also evidenced by clinical observations that men in some age categories are infected by this novel coronavirus up to two times more frequently than women. In addition, men with androgenic alopecia tend to have more serious clinical courses, while men with androgen deprivation as a result of prostate cancer treatments tend to have milder courses. This is in line with the fact that preadolescent children are only rarely sickened with serious forms of SARS-CoV-2 infections. Even though these observations may be explained by other factors, many authors have hypothesized that lowered androgen levels and blocking their activity using anti-androgen medication may moderate the course of the viral infection in intermediately- to critically-affected cases. Clearly, it would be important for androgen deprivation to block not just gonadal androgens, but also adrenal androgens. On the other hand, low androgen levels are considered to be a risk factor for the course of SARS-CoV-2 infections, either because low androgen levels have a general effect on anaboliccatabolic equilibrium and energy metabolism, or because of the ability of testosterone to modify the immune system. It is not yet clear if infection with this novel coronavirus might induce hypogonadism, leading to undesirable side effects on male fertility.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

S145-S151

Source:

Physiological research | 2021 Volume:70 | Number:Supplement 2

Harvested from:

CDK

Metadata only:

false