Plasma concentrations of adipocyte fatty acid binding protein in patients with Cushing's syndrome

Title:

Plasma concentrations of adipocyte fatty acid binding protein in patients with Cushing's syndrome

Creator:

Viktória Ďurovcová, Marek, J., Václav Hána, Martin Matoulek, Vít Zikán, Denisa Haluzíková, Petra Kaválková, Zdeňka Lacinová, Michal Kršek, and Martin Haluzík

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e60ff497-2533-426b-bd08-c472e4653162
uuid:e60ff497-2533-426b-bd08-c472e4653162
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, obezita, obesity, adipocyte fatty acid binding protein 4, hypercortisolism, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Serum adipocyte fatty acid-binding protein (FABP-4) concentrations are linked to human obesity and other features of metabolic syndrome. Patients with Cushing's syndrome (CS) develop numerous features of metabolic syndrome due to chronic cortisol excess. Here we tested the hypothesis that chronically increased cortisol levels in CS patients may alter circulating levels of FABP-4. Fourteen patients with CS, 19 patients with simple obesity (OB) and 36 healthy control subjects (C) were included in the study. Serum FABP-4 concentrations were significantly higher in both CS and OB patients relati ve to C group, but they did not differ between CS and OB groups. In a combined population of all groups, serum FABP-4 levels correlated positively with BMI, body fat content, serum glucose, triglycerides, HbA1c and HOMA index and were inversely relate d to HDL-cholesterol, resting energy expenditure and freeT3 levels. We conclude that FABP-4 levels are significantly increased in both patients with simple obesity and obese patients with Cushing's syndrome. We suggest that increased FABP-4 concentrations in CS patients are rather due to their excessive fat accumulation and related metabolic abnormalities than due to a direct effect of cortisol on FABP-4 production., V. Ďurovcová, J. Marek, V. Hána, M. Matoulek, V. Zikán, D. Haluzíková, P. Kaválková, Z. Lacinová, M. Kršek, M. Haluzík., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:6

Harvested from:

CDK

Metadata only:

false