Opioid receptors in the rat spinal cord after longlasting deafferentation

Title:

Opioid receptors in the rat spinal cord after longlasting deafferentation

Creator:

Hájek, I., Buřitová, J., and Kříž, N.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e56b0e65-db08-4194-8ca9-738942cc6774
uuid:e56b0e65-db08-4194-8ca9-738942cc6774

Subject:

opioid receptors, spinal cord, and deafferentation

Type:

article, model:article, and TEXT

Description:

In vitro binding of specific opioid ligands to their respective sites in membrane fractions and the contribution of individual receptor classes (mu, delta, kappa) was studied in rats after longlasting (up to 22 months) section of spinal dorsal roots at the cervical (C5.8) or thoracic (Th^) level. This procedure leads to autotomy or scratching of the skin on the operated side. The total number of receptors in the cervical and thoracic spinal cord was more than doubled in both operated and contralalteral part of the cord in comparison with intact controls of the same age. In the cervical region, this increase mainly represented a rise in the number of free receptors, whilst in the thoracic region both free and saturated receptors were increased. On the deafferented side, receptor selectivity, especially in the delta and kappa types was decreased.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1992 Volume:41 | Number:4

Harvested from:

CDK

Metadata only:

false