An antagonist of GABA-B receptors potentiates activity of cortical epileptic foci

Title:

An antagonist of GABA-B receptors potentiates activity of cortical epileptic foci

Creator:

Pavel Mareš, Klára Bernášková, and Hana Kubová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e0473a48-0d8a-49c6-859a-0f91b3d6416b
uuid:e0473a48-0d8a-49c6-859a-0f91b3d6416b

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, cerebral cortex, bicuculline, CGP35348, epileptic focus, rat, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Cortical epileptic foci elicited by local application of bicuculline methiodide represent a model of interictal epileptic activity with a transition into ictal phases. We studied a role of GABA-B receptors in this model using GABA-B receptor antagonist CGP35348 in adult rats with implanted cortical electrodes and cannula. CGP35348 (100 or 200 mg/kg i.p.) did not affect interictal discharges but it augmented ictal activity. Latency to the first ictal episode was decreased by the lower dose of CGP35348, duration of episodes was increased by the higher dose. GABA-B receptor antagonist did not influence purely cortical epileptic phenomenon but it is proconvulsant in ictal activity generated with participation of subcortical structures., P. Mareš, K Bernášková, H. Kubová., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:3

Harvested from:

CDK

Metadata only:

false