The arteriolar glycocalyx plays a role in the regulation of blood flow in the iliac of the anaesthetised pig

Title:

The arteriolar glycocalyx plays a role in the regulation of blood flow in the iliac of the anaesthetised pig

Creator:

Ruane-O’Hora, T and Markos, F

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:de40f8ab-3175-4584-b1e2-075b65e56a70
uuid:de40f8ab-3175-4584-b1e2-075b65e56a70
issn:0862-8408

Subject:

fyziologie člověka, human physiology, Glycocalyx, N-Formylmethionyl-leucyl-phenylalanine (fMLP), Hyaluronidase, Blood flow, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

The role of the glycocalyx of arterial resistance vessels in regulating blood flow in vivo is not fully understood. Therefore, the effect of glycocalyx damage using two separate compounds, hyaluronidase and N-Formylmethionyl-leucyl-phenylalanine (fMLP), was evaluated in the iliac artery vascular bed of the anaesthetised pig. Blood flow and pressure were measured in the iliac, an adjustable snare was applied to the iliac above the pressure and flow measurement site to induce step decreases (3 occlusions at 3-4 min intervals were performed for each infusion) in blood flow, and hence iliac pressure, and vascular conductance (flow/pressure) was calculated. Saline, hyaluronidase (14 and 28 μg/ml/min), and fMLP (1 μM/min) were infused separately, downstream of the adjustable snare and their effect on arterial conductance assessed. Hyaluronidase at the higher infusion rate and fMLP both caused a reduction in arterial conductance, and hence an increase in blood flow resistance. In conclusion, the results show that glycocalyx damage causes an increase in resistance to blood flow in the iliac artery vascular bed., T. Ruane-O’Hora, F. Markos., and Seznam literatury

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:1

Harvested from:

CDK

Metadata only:

false