Contractile effects of endothelins on isolated human ureter

Title:

Contractile effects of endothelins on isolated human ureter

Creator:

Jankovic, S. M., Jankovic, S. V., Stojanovic, V., Stojadinovic, D., Stojadinovic, M., Canovic, D., and Stefanovic, S.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:dc11c0c2-3a50-437d-a72b-76e43fa7ce56
uuid:dc11c0c2-3a50-437d-a72b-76e43fa7ce56

Subject:

Fyziologie člověka a srovnávací fyziologie, hladké svaly, smooth muscles, endothelins, human ureter, intraluminal pressure, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The aim of our study was to inve stigate mechanism of action of endothelins 1, 2 and 3 on spontaneous activity, tone and intraluminal pressure of human ureter. Both longitudinal tension and intraluminal pressure were recorded from the isolated segments of proximal human ureter. Endothelins 1, 2 and 3 (5.35x10 -11 M- 5.05x10-8M) produced concentration-dependent tonic contraction and sustained increase in intraluminal pressure of isolated preparations of hum an ureter. Endo thelins 1 and 3 produced also concentration-dependent inhibition of spontaneous, phasic contractions of the isolated preparations. Selective antagonist of ETA receptors BQ123 and selective antagonist of ET B receptors BQ788 produced significant inhibition of endothelin-1-induced tonic contraction (pA2=8.80 and 6.55, respectively) and increase in intraluminal pressure (pA2=8.68 and 7.02, respectively), while they did not affect endothelin-1-induced inhibition of spontaneous activity. Endothelin 1 produces increase in tone and intraluminal pressure of isolated human ureter acting on both ETA and ETB receptors, the first one being functionally more important. On ly endothelins 1 and 3 inhibit spontaneous, phasic activity of human ureter, but this effect was not blocked by selective antagonists of ETA and ETB receptors., S. M. Jankovic ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:6

Harvested from:

CDK

Metadata only:

false