The VO2-on kinetics in constant load exercise sub-anaerobic threshold reflects endothelial function and dysfunction in muscle microcirculation

Title:

The VO2-on kinetics in constant load exercise sub-anaerobic threshold reflects endothelial function and dysfunction in muscle microcirculation

Creator:

Maione, D., Cicero, A. F. G., Bacchelli, S., Cosentino, E. R., Degli Esposti, D., Manners, D. N., Rinaldi, E. R., Rosticci, M., Senaldi, R., Ambrosioni, E., and Borghi, C.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:dbfb3337-6787-4429-955e-3b5922b501ac
uuid:dbfb3337-6787-4429-955e-3b5922b501ac
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, anaerobic threshold, constant load exercise, endothelial function, O2 consumption, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

To propose a test to evaluate endothelial function, based on VO 2 on-transition kinetics in sub -anaerobic threshold (AT) constant load exercise, we tested healthy subjects and patients with ischemic -hypertensive cardiopathy by two cardiopulmonary te sts on a cycle ergometer endowed with an electric motor to overcome initial inertia: a pre-test and, after at least 24 h, one 6 min constant load exercise at 90 % AT. We measured net phase 3 VO2-on kinetics and, by phase 2 time constant (τ), valued endothe lial dysfunction. We found shorter τ in repeated tests, shorter time between first and second test, by persisting endothelium -dependent arteriolar vasodilatation and/or several other mechanisms. Reducing load to 80 % and 90 % AT did not produce significant changes in τ of healthy volunteers, while in heart patients an AT load of 70 %, compared to 80 % AT, shortened τ(∆=4.38±1.65s, p=0.013). In heart patients, no correlation was found between NYHA class, ejection fraction (EF), and the two variables derived from incremental cycle cardio - pulmonary exercise, as well as between EF and τ; while NYHA class groups were well correlated w ith τ duration (r=0.92, p=0.0001). Doxazosin and tadalafil also significantly reduced τ. In conclusion, the O2 consumption kinetics during the on transition of constant load exercise below the anaerobic threshold are highly sensitive to endothelial functi on in muscular microcirculation, and constitute a marker for the evaluation of endothelial dysfunction. and D. Maione, A. F. G. Cicero, S. Bacchelli, E. R. Cosentino, D. Degli Esposti, D. N. Manners, E. R. Rinaldi, M. Rosticci, R. Senaldi, E. Ambrosioni, C. Borghi.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:6

Harvested from:

CDK

Metadata only:

false