Natriuretic peptides - physiology, pathophysiology and clinical use in heart failure

Title:

Natriuretic peptides - physiology, pathophysiology and clinical use in heart failure

Creator:

Jan Krupička, Tomáš Janota, Zdislava Kasalová, and Jaromír Hradec

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:dbe2ba28-40ee-46da-9479-b0aa609f0d37
uuid:dbe2ba28-40ee-46da-9479-b0aa609f0d37

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, srdeční selhání, natriuretické peptidy, physiology, heart failure, natriuretic peptides, heart failure diagnosis, heart failure treatment, BNP, NT-proBNP, Optima Study, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The natriuretic peptides - atrial, brain and C-type - were discovered during the last tw enty years. Their effects on cardiovascular, renal, cerebral and other tissues through guanylyl cyclase were uncovered. Over the past decade natriuretic peptides (NPs) became a very useful tool in the management of heart failure patients. Results of many clinical trials have shown that BNP and NT-proBNP are helpful for diagnosis of heart failure. They are also independent markers of prognosis not only in heart failure patients but also in patients with other cardiovascular diseases. Recently published data document the utility of NPs in guiding treatment of heart failure patients. In this article, we focus on basic biochemical and physiological characteristics of NPs as well as on their significance in management of heart failure patients. Some limitations and pitfalls of NPs levels interpretation in diagnosing heart failure are also discussed., J. Krupička ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:2

Harvested from:

CDK

Metadata only:

false