Skin blood flowmotion and microvascular reactivity investigation in hypercholesterolemic patients with out clinically manifest arterial diseases

Title:

Skin blood flowmotion and microvascular reactivity investigation in hypercholesterolemic patients with out clinically manifest arterial diseases

Creator:

Rossi, M., Carpi, A., Di Maria, C., Franzoni, F., Galetta, F., and Santoro, G.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:dba6ef23-db85-4447-99f3-2295912c5294
uuid:dba6ef23-db85-4447-99f3-2295912c5294

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, hypercholesterolémie, acetylcholin, Fourierova analýza, physiology, hypercholesterolemia, acetylcholine, Fourier analysis, endothelial function, laser Doppler flowmetry, flowmotion, sodium nitroprusside, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Fourier spectral analysis of fore arm skin laser Doppler flowmetry (LDF) signal was performed in fifteen hypercholesterolemic patients (HP), without clinically manifest arterial diseases, and in fifteen age-matched healthy control subjects (CS), in order to investigate skin blood flowmotion (SBF). The LDF frequency intervals studied were: 0.01-1.6 Hz total spectrum, as well as 0.01-0.02 Hz (endothelial), 0.02-0. 06 Hz (sympathetic), 0.06-0.2 Hz (myogenic), 0.2-0.6 Hz (respiratory) and 0.6-1.6 Hz (cardiac). Skin microvascular reactivity (MVR ) to acetylcholine (ACh) and to sodium nitroprusside (SNP) iontophoresis was also investigated. HP showed a lower post-ACh increase in power spectral density (PSD) of the 0.01-0.02 Hz SBF subinterval compared to CS (1.80±1.73 PU 2 /Hz vs 3.59±1.78 PU 2 /Hz, respectively; p<0.005), while they did not differ in MVR from CS. In eleven HP the 0.01-0.02 Hz SBF subinterval showed a higher post-ACh PSD increase near to the statistical significance after 10 weeks of rosuvastatin therapy (10 mg/day) compared to pretreatment test (3.04±2.95 PU 2 /Hz vs 1.91±1.94 PU 2 /Hz; p=0.07). The blunted post-ACh increase in PSD of the 0.01-0.02 Hz SBF subinterval in HP suggests a skin endothelial dysfunction in these patients. This SBF abnormality showed a tendency to improve after rosuvastatin therapy in eleven treated patients., M. Rossi ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:1

Harvested from:

CDK

Metadata only:

false