Hyperbilirubinemia decreases physiological markers in adjuvant-induced arthritis

Title:

Hyperbilirubinemia decreases physiological markers in adjuvant-induced arthritis

Creator:

Bauerova, K., Drafi, F., Kuncirova, V., Ponist, S., Danica Mihalová, Pavel Babál, and Sykora, T.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:db45d14e-54db-41c8-a020-8726bebcc94c
uuid:db45d14e-54db-41c8-a020-8726bebcc94c
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, bilirubin, artritida, arthritis, immunomodulation, inflammation markers, blood elements, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

There is evidence that a higher serum level of bilirubin (BIL) may be a protective factor for autoimmune diseases. We examined the effect of BIL supplementation in adjuvant-induced arthritis (AIA) where oxidative stress, inflammation and inadequate immune response are present. Male Lewis rats were randomized into groups: CO - control, AIA - untreated adjuvant-induced arthritis, AIA-BIL - adjuvant-induced arthritis administrated BIL (200 mg/kg b.w. daily i.p. during 14 days). Change of hind paw volume in the AIA-BIL group in comparison to the AIA group was significantly decreased after BIL administration. In CO and AIA groups we found almost untraceable levels of BIL. In the AIA-BIL group hyperbilirubinemia was observed. BIL administration significantly decreased plasma levels of C-reactive protein and ceruloplasmin in the AIA-BIL group in comparison to the AIA group. The values of white and red blood cells, hemoglobin and hematocrit were significantly decreased in AIA-BIL after BIL supplementation. Organs like spleen and thymus had a lower weight in AIA-BIL than in AIA. Histological findings showed decreased or even absent damage in hind paw joint of AIA-BIL animals. We observed an immunomodulatory effect of BIL on AIA development, which may also have a novel pharmacological impact., K. Bauerova, F. Drafi, V. Kuncirova, S. Ponist, D. Mihalova, P. Babal, T. Sykora., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:Suppl 4

Harvested from:

CDK

Metadata only:

false