Calsequestrin distribution, structure and function, its role in normal and pathological situations and the effect of thyroid hormones

Title:

Calsequestrin distribution, structure and function, its role in normal and pathological situations and the effect of thyroid hormones

Creator:

Novák, P. and Tomáš Soukup

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:da8501f2-1837-4ff4-854b-f622c0269b61
uuid:da8501f2-1837-4ff4-854b-f622c0269b61

Subject:

Fyziologie člověka a srovnávací fyziologie, hormony štítné žlázy, svaly, thyroid hormones, muscles, skeletal and heart muscle, calsium binding proteins, calsequestrin, muscle pathology, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Calsequestrin is the main calcium binding protein of the sarcoplasmic reticulum, serving as an important regulator of Ca 2+ . In mammalian muscles, it exis ts as a skeletal isoform found in fast- and slow-twitch skeletal muscles and a cardiac isoform expressed in the heart and slow-twitch muscles. Recently, many excellent reviews that summarised in great detail various aspects of the calsequestrin structure, localisation or function both in skeletal and cardiac muscle have appeared. The present review focuses on skeletal muscle: information on cardiac tissue is given, where differences between both tissues are functionally important. The article reviews the known multiple roles of calsequestrin including pathology in order to introduce this topic to the broader scientific community and to stimulate an interest in this protein. Newly we describe our results on the effect of thyroid hormones on skeletal and cardiac calsequestrin expression and discuss them in the context of available literary data on this topic., P. Novák, T. Soukup., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:3

Harvested from:

CDK

Metadata only:

false