Steroid hormone levels in the peripartum period: differences caused by fetal sex and delivery type

Title:

Steroid hormone levels in the peripartum period: differences caused by fetal sex and delivery type

Creator:

Karolína Adamcová, Lucie Kolátorová Sosvorová, Škodová, T, Marie Šimková, Antonín Pařízek, Luboslav Stárka, and Michaela Dušková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d817518d-896b-4b18-a687-867738c84358
uuid:d817518d-896b-4b18-a687-867738c84358
issn:0862-8408

Subject:

novorozenci, steroidy, sex, newborns, steroids, delivery, physiological range, cord blood, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Progesterone, estrogens, androgens and glucocorticoids all play important roles during pregnancy, from implantation to delivery. Focusing on selected steroid hormones in the peripartum period, we defined reference ranges measured using LS-MS/MS, and assessed relationships with maternal age, pregnancy weight gain, delivery type, and fetal sex. Samples were taken from 142 healthy women with physiological gravidity at the 37th week, during the first period of labor, and from newborn mixed cord blood. We found higher cortisol and 17-OH-pregnenolone plasma levels in mothers at the 37th week that carried male fetuses (p=0.03), but no significant differences in any studied hormones in newborns of different sex. Neither maternal age nor weight gain nor newborn birth weight had any relationships to any of the studied hormones. However, there were differences depending on vaginal versus planned cesarean section deliveries. In women carrying a male fetus we found significantly higher levels of 17-OH-pregnenolone, progesterone, cortisol, corticosterone and significantly lower levels of estradiol in those undergoing spontaneous vaginal delivery. However, we found no significant differences in the cord blood of newborn males from either delivery type. We established reference ranges for our analysis methods, which should be useful for further studies as well as in standard clinical practice., K. Adamcová, L. Kolátorová, T. Škodová, M. Šimková, A. Pařízek, L. Stárka, M. Dušková., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:Suppl 3

Harvested from:

CDK

Metadata only:

false