Meal test for glucose-dependent insulinotropic peptide (GIP) in obese and type 2 diabetic patients

Title:

Meal test for glucose-dependent insulinotropic peptide (GIP) in obese and type 2 diabetic patients

Creator:

Jan Škrha, Jiřina Hilgertová, Jarolímková, M., Marie Kunešová, and Martin Hill

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d6ef969d-9060-4e20-82c3-cd6b7c245182
uuid:d6ef969d-9060-4e20-82c3-cd6b7c245182

Subject:

Fyziologie člověka a srovnávací fyziologie, diabetes mellitus, glucose-dependent insulinotropic peptide, type 2 diabetes mellitus, obese non-diabetic subjects, insulin secretion, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Glucose-dependent insulinotropic peptide (GIP) contributes to incretin effect of insulin secretion which is impaired in Type 2 diabetes mellitus. The aim of this study was to introduce a simple meal test for evaluation of GIP secretion and action and to examine GIP changes in Type 2 diabetic patients. Seventeen Type 2 diabetic patients, 10 obese non-diabetic and 17 nonobese control persons have been examined before and after 30, 60 and 90 min stimulation by meal test. Serum concentrations of insulin, C-peptide and GIP were estimated during the test. Impaired GIP secretion was found in Type 2 diabetic patients as compared with obese non-diabetic and non-obese control persons. The AUCGIP during 90 min of the meal stimulation was significantly lower in diabetic patients than in other two groups (p<0.03). Insulin concentration at 30 min was lower in diabetic than in non-diabetic persons and the GIP action was delayed. The ΔIRI/ΔGIP ratio increased during the test in diabetic patients, whereas it progressively decreased in obese and nonobese control persons. Simple meal test could demonstrate impaired GIP secretion and delayed insulin secretion in Type 2 diabetic patients as compared to obese non-diabetic and nonobese healthy control individuals., J. Škrha., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:5

Harvested from:

CDK

Metadata only:

false