Monitoring of early and advanced glycation in relation to occurrence of microvascular complications in children and adolescents with type 1 diabetes mellitus

Title:

Monitoring of early and advanced glycation in relation to occurrence of microvascular complications in children and adolescents with type 1 diabetes mellitus

Creator:

Kostolanská, J., Vladimír Jakuš, and Barák, Ľ.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d65d8cce-f209-408d-b833-b9410f9cc950
uuid:d65d8cce-f209-408d-b833-b9410f9cc950

Subject:

Fyziologie člověka a srovnávací fyziologie, biochemie, diabetologie, komplikace (lékařství), biochemistry, diabetology, complications of diseases, fructosamine, HbA1c, serum AGEs, glycation gap, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

The authors aimed to evaluate if the monitoring of serum advanced glycation end-products (s-AGEs) could help to predict a development of diabetic complications. Clinical and biochemical parameters including fructosamine (FAM), glycated hemoglobin (HbA1c) and serum AGEs were investigated in children and adolescents with 1 type diabetes with (+DC) and without (–DC) complications. FAM levels (in mmol/l) were significantly elevated in +DC diabetic group compared to –DC one (3.043±0.459 vs. 2.614±0.430; p<0.001) or to controls (3.043±0.459 vs. 1.620±0.340; p<0.001) as well as in –DC compared to controls (2.614±0.430 vs. 1.620±0.340; p< 0.001). HbA1c (in %) were significantly elevated in +DC diabetic group compared to –DC one (10.48±1.83 vs. 8.41±1.19; p<<0.001) or to controls (10.48±1.83 vs. 5.0±0.38, p<<0.001) and also in –DC compared to controls (8.41±1.19 vs. 5. 0±0.38; p<0.001). Serum AGEs levels (in A. U.) were significantly higher in +DC group than in –DC (73.0±14.09 vs. 65.8±9.05; p< 0.05) and in group +DC than in controls (73.0±14.09 vs. 60.17±13.78; p<0.05), whereas there was no difference between –DC and controls. FAM correlated with HbA1c in both diabetic groups (+DC: r=0.374; p<0.05; –DC: r=0.719; p<0.001), but not in controls. Serum AGEs were correlated with Hb A1c (r=0.478; p=0.003) in +DC, but not in –DC or controls. Enhanced serum AGEs levels show that they could be not only an attendant phenomenon of microangiopathies, but also a predictor of their development., J. Kostolanská, V. Jakuš, Ľ. Barák., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:4

Harvested from:

CDK

Metadata only:

false