Differential regulation of preovulatory luteinizing hormone and follicle-stimulating hormone release by opioids in the proestrous rat

Title:

Differential regulation of preovulatory luteinizing hormone and follicle-stimulating hormone release by opioids in the proestrous rat

Creator:

Kumru, S., Şimşek, M., Yilmaz, B., Sapmaz, E., Kutlu, S., Sandal, S., and Canpolat, S.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d4e6ac09-3226-44c2-8e9a-b89f394e9808
uuid:d4e6ac09-3226-44c2-8e9a-b89f394e9808
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, morfin, morphine, naloxone, LH, FSH, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

We have investigated the role of m- and k-opioid receptors in the central control of preovulatory LH and FSH release in the proestrous rat. Animals were anesthetized with chloral hydrate at 14:00 h on proestrus day. Following femoral artery cannulation, they were mounted in a stereotaxic apparatus. Morphine and U-50488H (benzene-acetamide methane sulphonate) were infused intracerebroventricularly either alone or in combination with naloxone and MR1452, respectively. Controls received sterile saline alone. Blood samples were obtained at hourly intervals between 15:00 h and 17:00 h. Plasma LH and FSH levels were measured by radioimmunoassay. Morphine did not significantly change plasma LH levels at 15:00 h and 16:00 h sampling intervals. A significant increase was observed at 17:00 h compared to the controls (p<0.05). U-50488H significantly increased LH levels at 16:00 h and 17:00 h (p<0.05). The co-administration of naloxone and MR1452 with m- and k-agonist had no significant effect on LH levels at any sampling interval. In all groups, LH levels showed a linear rise over the sampling period between 15:00 h and 17:00 h. None of the treatments significantly altered plasma FSH levels which however, declined towards the end of the afternoon surge. In conclusion, we suggest that the secretion of LH and FSH is differentially regulated by m- and k-opioid receptors. It is thought that in all groups chloral hydrate interfered with the LH surge secretory systems., S. Kumru, M. Şimşek, B. Yilmaz, E. Sapmaz, S. Kutlu, S. Sandal, S. Canpolat., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:4

Harvested from:

CDK

Metadata only:

false