Effects of pleuran (β-glucan isolated from Pleurotus ostreatus) on experimental colitis in rats

Title:

Effects of pleuran (β-glucan isolated from Pleurotus ostreatus) on experimental colitis in rats

Creator:

Viera Nosáľová, Pavel Bobek, Silvia Černá, Štefan Galbavý, and Svetoslav Štvrtina

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d4cb1c79-be79-42a6-95c6-9fbaa3ab5607
uuid:d4cb1c79-be79-42a6-95c6-9fbaa3ab5607
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, glukany, glucans, pleuran, acetic acid induced colitis, rats, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The effects of pleuran, ß-1,3 glucan isolated from Pleurotus ostreatus, were studied in a model of acute colitis induced by intracolonic administration of acetic acid. There was a reduction of the colonic damage score, colonic wet weight and wet/dry weight ratio 48 h after single luminal 2 % pleuran suspension pretreatment. Similar results were obtained after repeated intraperitoneal administration of pleuran in doses of 30 and 100 mg/kg. Pleuran given orally as a 10 % food component over 4 weeks was effective in reducing the extent of mucosal damage, but did not prevent the increase of myeloperoxidase in the injured colonic segment. In the segment without macroscopic evidence of inflammation, myeloperoxidase activity was significantly lower as documented by histological examination. The results indicate a possible role of this immunomodulator in the treatment of ulcerative colitis., V. Nosáľová, P. Bobek, S. Černá, Š. Galbavý, S. Štvrtina., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:6

Harvested from:

CDK

Metadata only:

false