The cardiovascular effects of central hydrogen sulfide are related to K(APT) channels activation

Title:

The cardiovascular effects of central hydrogen sulfide are related to K(APT) channels activation

Creator:

Liu, W.-Q., Chai, C., Li, X.-Y., Yuan, W.-J., Wang, W.-Z., and Lu, Y.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d37e692c-b668-4626-a7bd-e22139832be0
uuid:d37e692c-b668-4626-a7bd-e22139832be0

Subject:

Fyziologie člověka a srovnávací fyziologie, sulfan, krevní tlak, srdeční rytmus, hydrogen sulphide, blood pressure, heart rate, rat, hydrogen sulfide, central, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Hydrogen sulfide (H2S), an endogenous “gasotransmitter”, exists in the central nervous system. However, the central cardiovascular effects of endogenous H2S are not fully determined. The present study was designed to investigate the central cardiovascular effects and its possible mechanism in anesthetized rats. Intracerebrovent ricular (icv) injection of NaHS (0.17~17 μ g) produced a significant and dose-dependent decrease in blood pressure (BP) and heart rate (HR) (P<0.05) compared to control. The higher dose of NaHS (17 μ g, n=6) decreased BP and HR quickly of rats and 2 of them died of respiratory paralyse. Icv injection of the cystathionine beta-synthetase (CBS) activator s-adenosyl-L-methionine (SAM, 26 μ g) also produced a significant hypotension and bradycardia, which were similar to the results of icv injection of NaHS. Furthermore, the hypotension and bradycardia induced by icv NaHS were effectively attenuated by pretreatment with the KATP channel blocker glibenclamide but not with the CBS inhibitor hydroxylamine. The present study suggests that icv injection of NaHS produces hypotension and bradycardia, which is dependent on the KATP channel activation., W.-Q. Liu ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:5

Harvested from:

CDK

Metadata only:

false