Short-term fasting reduces the extent of myocardial infarction and incidence of reperfusion arrhythmias in rats

Title:

Short-term fasting reduces the extent of myocardial infarction and incidence of reperfusion arrhythmias in rats

Creator:

Šnorek, M., Daniel Hodyc, Šedivý, V., Ďurišová, J., Skoumalová, A., Wilhelm, J., Jan Neckář, František Kolář, and Jan Herget

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d2e2b558-36fc-4fb7-becf-06b66b5b7f97
uuid:d2e2b558-36fc-4fb7-becf-06b66b5b7f97

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, myocardial ischemia/reperfusion, arrhythmias, infarction, fasting, ketone bodies, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

The effect of three-day fasting on cardiac ischemic tolerance was investigated in adult male Wistar rats. Anesthetized open-chest animals (pentobarbitone 60 mg/kg, i.p.) were subjected to 20-min left anterior descending coronary artery occlusion and 3-h reperfusion for infarct size determination. Ventricular arrhythmias were monitored during ischemia and at the beginning (3 min) of reperfusion. Myocardial concentrations of beta-hydroxybutyrate and acetoacetate were measured to assess mitochondrial redox state. Short-term fasting limited the infarct size (48.5±3.3 % of the area at risk) compared to controls (74.3±2.2 %) and reduced the total number of premature ventricular complexes (12.5±5.8) compared to controls (194.9±21.9) as well as the duration of ventricular tachycardia (0.6±0.4 s vs. 18.8±2.5 s) occurring at early reperfusion. Additionally, fasting increased the concentration of beta-hydroxybutyrate and betahydroxybutyrate/acetoacetate ratio (87.8±27.0) compared to controls (7.9±1.7), reflecting altered mitochondrial redox state. It is concluded that three-day fasting effectively protected rat hearts against major endpoints of acute I/R injury. Further studies are needed to find out whether these beneficial effects can be linked to altered mitochondrial redox state resulting from increased ketogenesis., M. Šnorek ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:6

Harvested from:

CDK

Metadata only:

false