Muscle NMDA receptors regulate the resting membrane potential through NO-synthase

Title:

Muscle NMDA receptors regulate the resting membrane potential through NO-synthase

Creator:

Urazaev, A. Kh., Magsumov, S. T., Poletayev, G. I., Nikolsky, E. E., and Vyskočil, F.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d27b5b8e-1d5b-404f-a4fa-c1da575ac4d4
uuid:d27b5b8e-1d5b-404f-a4fa-c1da575ac4d4

Subject:

denervation, resting membrane potential, neuromuscular junction, NO synthase, and NMDA receptor

Type:

article, model:article, and TEXT

Description:

The early postdenervation depolarization of rat diaphragm muscle fibres (8-10 mV) is substantially smaller (3 mV) when muscle strips are bathed with 1 mM L-glutamate (GLÜ) or N-methyl-D-aspartate (NMDA). The effects of GLÜ and NMDA are not seen in the presence of aminophosphonovaleric acid (APV), a blocker of NMDA-subtype of glutamate receptors, 5 mM Mg2+ (which blocks NMDA-controlled ion channels) and L-nitroarginine methylester (NAME), an inhibitor of NO-synthase. This indicates that NMDA-subtype of GL(J receptors might be involved in the regulation of the membrane potential in muscle fibres, most probably through the NO-synthase system.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1995 Volume:44 | Number:3

Harvested from:

CDK

Metadata only:

false