Hindlimb suspension does not influence mechanical sensitivity, epidermal thickness, and peripheral nerve density in the glabrous skin of the rat hind paw

Title:

Hindlimb suspension does not influence mechanical sensitivity, epidermal thickness, and peripheral nerve density in the glabrous skin of the rat hind paw

Creator:

Tanaka, Y., Nakano, J., Hamaue, Y., Sekino, Y., Sakamoto, J., Kataoka, H., and Okita, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d1bbcd18-f788-4dc4-ad4a-2547a6ec7f6e
uuid:d1bbcd18-f788-4dc4-ad4a-2547a6ec7f6e

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, hindlimb suspension, mechanical hypersensitivity, epidermal thickness, peripheral nerve, stress, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Our aim was to investigate the influence of microgravity on the sensitivity of the skin to mechanical stimulation, epidermal thickness, peripheral nerve density in the upper dermis, and serum levels of a stress marker in a rat hindlimb suspension (HS) model. Thirty 8-week-old male Wistar rats were randomly divided into 3 groups: HS, n=10; sham HS, n=10; control, n=10. The suspension system was attached to rat tails in both the HS and sham-HS groups, but the hindlimbs were suspended only in the HS group. The HS and sham-HS groups were treated for 4 weeks. In behavioral tests using von-Frey filaments (n=5 in each group), mechanical hypersensitivity developed in the HS and sham HS groups. Serum corticosterone levels increased significantly in the HS and sham HS groups compared to the control group, and no changes in epidermal thickness or peripheral nerve density were observed immediately after the removal of HS (n=5 in each group). These data indicated that the mechanical hypersensitivity observed in the HS group was not caused by microgravity or inactivity, but rather by restraint stress. We suggest that microgravity does not affect skin sensitivity and histology in these animals., Y. Tanaka, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:1

Harvested from:

CDK

Metadata only:

false