Endothelial-mesenchymal transition or functional tissue regeneration - two outcomes of heart remodeling

Title:

Endothelial-mesenchymal transition or functional tissue regeneration - two outcomes of heart remodeling

Creator:

Šalingová, Barbara, Červenák, Zdenko, Adamičková, Adriana, Chromanicová, Nikola, Valášková, Simona, Gažová, Andrea, and Kyselovič, Ján

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:cfe2779b-d09b-4d17-aa06-b7e42742d9b1
uuid:cfe2779b-d09b-4d17-aa06-b7e42742d9b1
issn:0862-8408
doi:10.33549/physiolres.934780

Subject:

fyziologie člověka, kardiologie, human physiology, cardiology, Cardiac fibrosis, Endothelial-mesenchymal transition, Endothelial progenitor cells, Cardiac fibroblasts, Cardiomyocytes, Endothelial cells, Agiotensin II, Tumor Growth Factor-β, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Heart remodeling occurs as a compensation mechanism for the massive loss of tissue during initial heart failure and the consequent inflammation process. During heart remodeling fibroblasts differentiate to myofibroblasts activate their secretion functions and produce elevated amounts, of extracellular matrix (ECM) proteins, mostly collagen, that form scar tissue and alter the normal degradation of ECM. Scar formation does replace the damaged tissue structurally; however, it impedes the normal contractive function of cardiomyocytes (CMs) and results in longlasting effects after heart failure. Besides CMs and cardiac fibroblasts, endothelial cells (ECs) and circulating endothelial progenitor cells (cEPCs) contribute to heart repair. This review summarizes the current knowledge of EC-CM crosstalk in cardiac fibrosis (CF), the role of cEPCs in heart regeneration and the contribution of Endothelial-mesenchymal transition (EndoMT)., Barbara Šalingová, Zdenko Červenák, Andriana Adamičková, Nikola Chromanicová, Simona Valášková, Andrea Gažová, Ján Kyselovič., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

S13-S20

Source:

Physiological research | 2021 Volume:70 | Number:Supplement 1

Harvested from:

CDK

Metadata only:

false