Effect of acute and chronic simvastatin treatment on post-ischemic contractile dysfunction in isolated rat heart

Title:

Effect of acute and chronic simvastatin treatment on post-ischemic contractile dysfunction in isolated rat heart

Creator:

Ondrej Szárszoi, Jan Malý, Petr Ošťádal, Ivan Netuka, Josef Bešík, František Kolář, and Bohuslav Ošťádal

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:cee58624-6f03-4c0a-8259-105ff07937d4
uuid:cee58624-6f03-4c0a-8259-105ff07937d4
issn:0862-8408

Subject:

Experimentální medicína, fyziologie, kardiovaskulární nemoci, akutní stavy, physiology, cardiovascular diseases, acute states, simvastatin, isolated rat heart, ischemia/reperfusion injury, acute and chronic treatment, 14, and 616-092

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Statins are powerful lipid-lowering drugs, widely used in patients with hyperlipidemia and coronary artery disease. It was found, however, that statins appear to have a pleiotropic effect beyond their lipid-lowering ability. They exert anti-inflammatory, antithrombotic and antioxidant effects, increase nitric oxide production and improve endothelial dysfunction. The aim of our study was to examine the effect of chronic and acute treatment with simvastatin on the contractile function of the isolated perfused rat heart after ischemia/reperfusion injury. Contractile function was measured on isolated rat hearts, perfused according to Langendorff under constant pressure. The hearts were subjected to 20 min of global ischemia, followed by 40 min of reperfusion. To investigate the acute effect, simvastatin at a concentration of 10 μmol/l was added to the perfusion solution during reperfusion. In chronic experiments the rats were fed simvastatin at a concentration of 10 mg/kg for two weeks before the measurement of the contractile function. Acute simvastatin administration significantly increased reparation of the peak of pressure development [(+dP/dt)max] (52.9±8.2 %) after global ischemia, as compared with the control group (28.8±5.2 %). Similar differences were also observed in the time course of the recovery of [(+dP/dt)max]. Chronic simvastatin was without any protective effect. Our results reveal that the acute administration of simvastatin during reperfusion, unlike the chronic treatment, significantly reduced contractile dysfunction induced by ischemia/reperfusion injury. This supports the idea of possible cardioprotective effect of statin administration in the first-line therapy of the acute coronary syndrome., O. Szárszoi, J. Malý, P. Ošťádal, I. Netuka, J. Bešík, F. Kolář, B. Ošťádal., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:5

Harvested from:

CDK

Metadata only:

false