Effect of 6-OHDA on hypercapnicventilatory response in the rat model of Parkinson’s disease

Title:

Effect of 6-OHDA on hypercapnicventilatory response in the rat model of Parkinson’s disease

Creator:

Andrzejewski, K., Budzińska, K., and Kaczyńska, K.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:c9a03573-31b1-41ba-aa9a-df3ddb712834
uuid:c9a03573-31b1-41ba-aa9a-df3ddb712834
doi:10.33549/physiolres.933949

Subject:

Parkinson’s disease, 6-OHDA, Rat model, Hypercapnia, and Respiratory pattern

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Breathing impairments, such as an alteration in breathing pattern, dyspnoea, and sleep apnoea, are common health deficits recognised in Parkinson’s disease (PD). The mechanism that underlies these disturbances, however, remains unclear. We investigated the effect of the unilateral damage to the rat nigrostriatal pathway on the central ventilatory response to hypercapnia, evoked by administering 6-hydroxydopamine (6-OHDA) into the right medial forebrain bundle (MFB). The respiratory experiments were carried out in conscious animals in the plethysmography chamber. The ventilatory parameters were studied in normocapnic and hyperoxic hypercapnia before and 14 days after the neurotoxin injection. Lesion with the 6-OHDA produced an increased tidal volume during normoxia. The magnified response of tidal volume and a decrease of breathing frequency to hypercapnia were observed in comparison to the pre-lesion and sham controls. Changes in both respiratory parameters resulted in an increase of minute ventilation of the response to CO2 by 28 % in comparison to the pre-lesion state at 60 s. Our results demonstrate that rats with implemented unilateral PD model presented an altered respiratory pattern most often during a ventilatory response to hypercapnia. Preserved noradrenaline and specific changes in dopamine and serotonin characteristic for this model could be responsible for the pattern of breathing observed during hypercapnia.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

285-293

Source:

Physiological research | 2019 Volume:68 | Number:2

Harvested from:

CDK

Metadata only:

false