Twenty-four hour blood pressure profile in subjects with different subtypes of primary aldosteronism

Title:

Twenty-four hour blood pressure profile in subjects with different subtypes of primary aldosteronism

Creator:

Tomáš Zelinka and Jiří Widimský

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:c4384470-7169-40ca-9912-3aa83831a880
uuid:c4384470-7169-40ca-9912-3aa83831a880
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, krevní tlak, blood pressure, ambulatory blood pressure monitoring, primary aldosteronism, circadian blood pressure variability, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aim of our study was to evaluate the potential differences in blood pressure (BP) profile in subjects with different forms of primary aldosteronism (PA). Simultaneously, we studied the effects of PA treatment on BP curve. We therefore monitored 24-hour ambulatory blood pressure values in 22 subjects with aldosterone-producing adenoma (APA), 22 subjects with idiopathic hyperaldosteronism (IHA) and 33 subjects with essential hypertension (EH) as controls. We found a significantly attenuated nighttime systolic BP decline in the APA group (P=0.02). Patients with IHA had lower nighttime systolic BP values (P=0.01) and also a diastolic BP decline (P=0.02) during the night in comparison with EH. We did not detect any significant differences in BP profile characteristics between APA and IHA. Specific treatment of primary aldosteronism (adrenalectomy, treatment with spironolactone) led to the normalization of the BP curve with a marked BP decline. Our study thus demonstrates a blunted diurnal BP variability in patients with primary aldosteronism the specific treatment of which normalized previously attenuated nocturnal BP fall., T. Zelinka, J. Widimský., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:1

Harvested from:

CDK

Metadata only:

false