Association of metabolic and genetic factors with cholesterol esterification rate in HDL plasma and atherogenic index of plasma in a 40 years old Slovak population

Title:

Association of metabolic and genetic factors with cholesterol esterification rate in HDL plasma and atherogenic index of plasma in a 40 years old Slovak population

Creator:

Katarína Rašlová, Milada Dobiášová, Hubáček, J. A., Bencová, D., Daniela Siváková, Zdeňka Daňková, Franeková, J., Antonín Jabor, Gašparovič, J., and Branislav Vohnout

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:c42bc5ee-e602-4353-b235-fedb792e62bf
uuid:c42bc5ee-e602-4353-b235-fedb792e62bf

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, fractional esterification rate of cholesterol (FERHDL), atherogenic index of plasma (AIP), biomarkers of CVD, CILP2, FTO, MLXIPL, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

We assessed association between novel biomarkers of cardiovascular disease and conven tional factors in 40 years old subjects (208 men and 266 women) from the general population of Slovakia. FER HDL (cholesterol esterifi cation rate in HDL plasma), AIP - Atherogenic Index of Plasma [Log(TG/HDL-C)] as markers of lipoprotein particle size, and CILP2, FTO and MLXIPL polymorphisms, were examined in relation to biomarkers and conventional risk factors. Un ivariate analyses confirmed correlation between AIP, FERHDL and the most of measured parameters. Relations between AIP and CILP2, FTO and MLXIPL were not significant. However, CILP2 was significantly related to FERHDL in both genders. In multivariate analysis BMI was the strongest correlate of AIP levels. In multivariate model variability of FER HDL was best explained by AIP (R2 =0.55) in both genders with still significant effect of CILP2 SNP in men. In a model where AIP was omitted, TG leve ls explained 43 % of the FER HDL variability in men, while in women HDL-C was the major determinant (42 %). In conclusions, FERHDL and AIP related to the known markers of cardiovascular risk provide means to express their subtle interactions by one number. Our novel finding of association between CILP2 polymorphism and FERHDL supports its role in lipid metabolism., K. Rašlová ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:5

Harvested from:

CDK

Metadata only:

false