Crohn's disease: a role of gut microbiota and Nod2 gene polymorphisms in disease pathogenesis

Title:

Crohn's disease: a role of gut microbiota and Nod2 gene polymorphisms in disease pathogenesis
Crohn's disease: a role of gut microbiota and Nod2 gene polymorphisms in disease pathogenesis

Creator:

Hrnčířová, Lucia, Krejsek, Jan, Šplíchal, Igor, and Hrnčíř, Tomáš

Contributor:

Hrnčířová, Lucia, Krejsek, Jan , 1958-, Šplíchal, Igor, and Hrnčíř, Tomáš

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc15020406-2835b69e-ad34-4c35-a2d5-37cafbc86c2d
uuid:bmc15020406-2835b69e-ad34-4c35-a2d5-37cafbc86c2d
local:bmc15020406
http://actamedica.lfhk.cuni.cz/
doi: 10.14712/18059694.2014.46
local: bmc15020406

Subject:

Crohnova nemoc--genetika, gastrointestinální trakt--mikrobiologie, interakce genů a prostředí, genetická predispozice k nemoci, srovnávací asociační studie genomů, lidé, mikrobiota, signální adaptorový protein Nod2--genetika, and polymorfismus genetický

Type:

model:article, article, Text, časopisecké články, práce podpořená grantem, přehledy, and TEXT

Format:

print, text, and regular print

Description:

Crohn's disease is a chronic immune-mediated intestinal inflammation targeted against a yet incompletely defined subset of commensal gut microbiota and occurs on the background of a genetic predisposition under the influence of environmental factors. Genome-wide association studies have identified about 70 genetic risk loci associated with Crohn's disease. The greatest risk for Crohn's disease represent polymorphisms affecting the CARD15 gene encoding nucleotide-binding oligomerization domain 2 (NOD2) which is an intracellular sensor for muramyl dipeptide, a peptidoglycan constituent of bacterial cell wall. The accumulated evidence suggests that gut microbiota represent an essential, perhaps a central factor in the induction and maintaining of Crohn's disease where dysregulation of normal co-evolved homeostatic relationships between intestinal microbiota and host mucosal immune system leads to intestinal inflammation. Taken together, these findings identify Crohn's disease as a syndrome of overlapping phenotypes that involves variable influences of genetic and environmental factors. A deeper understanding of different genetic abnormalities underlying Crohn's disease together with the identification of beneficial and harmful components of gut microbiota and their interactions are essential conditions for the categorization of Crohn's disease patients, which enable us to design more effective, preferably causative, individually tailored therapy. and L. Hrnčířová, J. Krejsek, I. Šplíchal, T. Hrnčíř

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové) Universitas Carolina, Facultas Medica Hradec Králové--MED00010947

Source:

Acta medica (Hradec Králové) | 2014 Volume:57 | Number:3

Harvested from:

CDK

Metadata only:

false

Date:

2014