Association of carotid intima-media thickness with leptin and apoliprotein b/apoliprotein a-I ratio reveals imminent predictors of subclinical atherosclerosis in psoriasis patients

Title:

Association of carotid intima-media thickness with leptin and apoliprotein b/apoliprotein a-I ratio reveals imminent predictors of subclinical atherosclerosis in psoriasis patients
Association of carotid intima-media thickness with leptin and apoliprotein b/apoliprotein a-I ratio reveals imminent predictors of subclinical atherosclerosis in psoriasis patients

Creator:

Asha, Kumari, Sharma, Suman B., Singal, Archana, and Aggarwal, Amitesh

Contributor:

Asha, Kumari, Sharma, Suman B., Singal, Archana, and Aggarwal, Amitesh

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc14071293-8923ffc3-4a34-4738-a102-326cf17e24e3
uuid:bmc14071293-8923ffc3-4a34-4738-a102-326cf17e24e3
local:bmc14071293
https://www.lfhk.cuni.cz/Faculty/Publications/Acta-Medica/Archive/2014/Acta-Medica-2014-Vol-57-No-1/
local: bmc14071293

Subject:

dospělí, apolipoprotein A-I--krev, apolipoproteiny B--krev, ateroskleróza--krev--diagnóza--etiologie, intimomediální šíře tepenné stěny, studie případů a kontrol, ženské pohlaví, lidé, leptin--krev, mužské pohlaví, lidé středního věku, prediktivní hodnota testů, and psoriáza--krev--komplikace--ultrasonografie

Type:

model:article, article, Text, časopisecké články, práce podpořená grantem, and TEXT

Format:

print, text, and regular print

Description:

Psoriasis patients are often susceptible to cardiovascular diseases (CVD), including atherosclerosis. Traditional markers (biochemical and inflammatory) and diagnostic tools could detect occlusive but not subclinical atherosclerosis. Carotid intima-media thickness (CIMT), has recently been recognised as a non invasive diagnostic tool for identification of premature atherosclerosis. Therefore we evaluated 80 psoriasis patients and 80 age sex matched healthy controls for serum leptin levels and apolipoprotein B/apolipoprotein A-I ratio (apoB/apoA-I ratio) in relation with CIMT of carotid artery. Carotid intima-media thickness and carotid plaques were simultaneously measured by carotid sonography. Serum concentration of leptin and apolipoprotein were measured using enzyme-linked immuno sorbent assay (ELISA) and nephelometry respectively. Raised CIMT correlated to age of onset of the disease, serum leptin and apoB/apoA-I ratio in psoriasis patients. Taking into account, values that were above the 75 percentile of the three markers (leptin, apoB/apoA-I ratio and CIMT) the odds ratio was 4.26 (2.06-8.80 CI). Leptin and apoB/apoA-I ratio showed significant cumulative association with CIMT. Results of predictive analysis supports measurement of CIMT along with estimation of serum leptin and apoB/apoA-I ratio for prediction of premature atherosclerosis in psoriasis patients. and K. Asha, S. B. Sharma, A. Singal, A. Aggarwal

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové--MED00010947

Source:

Acta medica (Hradec Králové) | 2014 Volume:57 | Number:1

Harvested from:

CDK

Metadata only:

false

Date:

2014