The effect of L-carnosine on erythrocyte deformability and aggregation according to the cell age in young and aged rats

Title:

The effect of L-carnosine on erythrocyte deformability and aggregation according to the cell age in young and aged rats
The effect of L-carnosine on erythrocyte deformability and aggregation according to the cell age in young and aged rats

Creator:

Erken, Gülten, Bor-Kucukatay, Melek, KilicToprak, Emine, Akdag, Beyza, and Kucukatay, Vural

Contributor:

Erken, Gülten, Bor-Kucukatay, Melek, KilicToprak, Emine, Akdag, Beyza, and Kucukatay, Vural

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc14059435-32500657-d410-4449-8716-40fb11c5deb2
uuid:bmc14059435-32500657-d410-4449-8716-40fb11c5deb2
local:bmc14059435
https://www.lfhk.cuni.cz/Faculty/Publications/Acta-Medica/Archive/2013/
local: bmc14059435

Subject:

věkové faktory, zvířata, karnosin--farmakologie, stárnutí buněk--fyziologie, erytrocyty - agregace--účinky léků, erytrocyty - měnlivost tvaru--účinky léků, mužské pohlaví, oxidační stres--fyziologie, krysy, and potkani Sprague-Dawley

Type:

model:article, article, Text, časopisecké články, and TEXT

Format:

print, text, and regular print

Description:

This study aimed to investigate alterations in hemorheology induced by L-carnosine, an anti- oxidant dipeptide, and to determine their relationship to oxidative stress in density-separated erythrocytes of aged and young rats. 28 male Sprague Dawley rats were divided into 4 groups as aged (Aca), young (Yca) L-carnosine groups (250 mg/kg L-carnosine, i.p.) and aged (As), young (Ys) control groups (saline, i.p.). Density separation was further performed to these groups in order to separate erythrocytes according to their age. Blood samples were used for the determination of erythrocyte deformability, aggregation; and oxidative stress parameters. Erythrocyte deformability of Yca group measured at 0.53 Pa was lower than Aca group. Similarly, deformability of least-dense (young) erythrocytes of Yca group was decreased compared to least-dense erythrocytes of Aca groups. Total antioxidant capacity (TAC) of Aca group was higher and oxidative stress index (OSI) lower than As group. Although L-carnosine resulted in an enhancement in TAC of aged rats, this favorable effect was not observed in erythrocyte deformability and aggregation in the dose applied in this study. and G. Erken, M. Bor-Kucukatay, E. KilicToprak, B. Akdag, V. Kucukatay

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové--MED00010947

Source:

Acta medica (Hradec Králové) | 2013 Volume:56 | Number:1

Harvested from:

CDK

Metadata only:

false

Date:

2013