Effect of collagen I gel on apoptosis of rat hepatic stellate cells

Title:

Effect of collagen I gel on apoptosis of rat hepatic stellate cells
Effect of collagen I gel on apoptosis of rat hepatic stellate cells

Creator:

Bittnerová, Lenka, Jiroutová, Alena, Rudolf, Emil, Řezáčová, Martina, and Kanta, Jiří

Contributor:

Bittnerová, Lenka, Jiroutová, Alena, Rudolf, Emil , 1970-, Řezáčová, Martina , 1972-, and Kanta, Jiří , 1943-

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc14059426-b2c668e7-d41f-4ddf-b385-8a87406ca7ba
uuid:bmc14059426-b2c668e7-d41f-4ddf-b385-8a87406ca7ba
local:bmc14059426
https://www.lfhk.cuni.cz/Faculty/Publications/Acta-Medica/Archive/2013/
local: bmc14059426

Subject:

zvířata, apoptóza--účinky léků, chlorid uhličitý, buněčné kultury, kolagen typu I--farmakologie, cykloheximid, cytochalasin D, modely nemocí na zvířatech, gliotoxin, jaterní hvězdicovité buňky--účinky léků--patologie, jaterní cirhóza--patologie, mužské pohlaví, krysy, and potkani Sprague-Dawley

Type:

model:article, article, Text, časopisecké články, práce podpořená grantem, and TEXT

Format:

print, text, and regular print

Description:

Activated hepatic stellate cells (HSC) are a major source offibrous proteins in cirrhotic liver. Inducing or accelerating their apoptosis is a potential way of liver fibrosis treatment. Extracellular matrix (ECM) surrounding cells in tissue affects their differentiation, migration, proliferation and function. Type I collagen is the main ECM component in fibrotic liver. We have examined how this protein modifies apoptosis of normal rat HSC induced by gliotoxin, cycloheximide and cytochalasin D in vitro and spontaneous apoptosis of HSC isolated from CCl4-damaged liver. We have found that type I collagen gel enhances HSC apoptosis regardless of the agent triggering this process. and L. Bittnerová, A. Jiroutová, E. Rudolf, M. Rezácová, J. Kanta

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové--MED00010947

Source:

Acta medica (Hradec Králové) | 2013 Volume:56 | Number:2

Harvested from:

CDK

Metadata only:

false

Date:

2013