Effect of DRD2/ANKK1 taqIA allelic polymorphism on the risk and prognosis of cervical precancer and cancer

Title:

Effect of DRD2/ANKK1 taqIA allelic polymorphism on the risk and prognosis of cervical precancer and cancer
Effect of DRD2/ANKK1 taqIA allelic polymorphism on the risk and prognosis of cervical precancer and cancer

Creator:

Cseh, József, Orsós, Zsuzsa, Pázsit, Emese, Marek, Erika, Huszár, András, Ember, István, and Kiss, István

Contributor:

Cseh, József, Orsós, Zsuzsa, Pázsit, Emese, Marek, Erika, Huszár, András, Ember, István, and Kiss, István

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc14046146-88929ceb-56eb-45f7-97cb-55f7e29ec5ed
uuid:bmc14046146-88929ceb-56eb-45f7-97cb-55f7e29ec5ed
local:bmc14046146
http://ojs.journals.cz/index.php/EMHPJ/issue/archive
local: bmc14046146

Subject:

cervikální intraepiteliální neoplazie--etiologie--genetika, prekancerózy--genetika, cervix uteri--patologie, infekce papilomavirem, genotyp, receptory dopaminu D2--genetika, riziko, protein-serin-threoninkinasy--genetika, polymorfismus délky restrikčních fragmentů--genetika, polymorfismus genetický, prognóza, nádory děložního čípku--genetika, genetická predispozice k nemoci, následné studie, mladiství, dospělí, ženské pohlaví, lidé, menarche, A1/A1, A1/A2, and A2/A2

Type:

model:article, article, Text, statistics, and TEXT

Format:

braille, electronic resource, remote, and elektronický zdroj

Description:

Objectives: The aim of this study was to elucidate the role of dopamine receptor D2 / ankyrin repeat and protein kinase domain containing 1 (DRD2/ANKK1) TaqIA allelic polymorphism in the HPVinduced cervical carcinogenesis. Methods: 1. Effect on the risk of cervical precancer: After an 8year followup, out of 214 women with persisting highrisk HPV infection, 102 developed highgrade cervical dysplasia or cervical intraepithelial neoplasia (CIN) grade III, while 112 did not. The subjects were genotyped for the DRD2/ANKK1 TaqIA polymorphism by PCRRFLP, and the allelic distributions were compared between groups with and without highgrade dysplasia. 2. Prognostic value: Two hundred and thirty nine women with cervical precancer/cancer were followed for 5 years. Complete remission was achieved at 182 women. To assess the prognostic value of the TaqIA polymorphism, genotype frequencies were compared between patients reaching and not reaching complete remission. Results: The frequency of A1/A1+A1/A2 genotypes was higher among women who developed highgrade cervical dysplasia (OR: 1.87, 95% CI: 1.053.33; p=0.034) than in the other group. Occurrence of the A1 allele was more frequent among women who did not reach complete remission (OR: 2.00, 95% CI: 1.073.74; p=0.030) than in women with complete remission. Conclusions: This is the first report on the possible involvement of DRD2/ANKK1 TaqIA polymorphism in cervical carcinogenesis. The A1 allele seems to increase the risk of cervical precancer, and it may also be associated with a worse prognosis in women with HPVinduced cervical cancer. The results need further validation in largescale molecular epidemiological studies., József Cseh, Zsuzsa Orsós, Emese Pázsit, Erika Marek, András Huszár, István Ember, István Kiss, and Literatura

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

European medical, health and pharmaceutical journal--MED00177703

Source:

European medical, health and pharmaceutical journal : open access reviewed journal | 2012 Volume:2012 | Number:4

Harvested from:

CDK

Metadata only:

false

Date:

2012