The study drug pathomorphism and immunohistochemical parameters of tumor in endoarterial of regional long-term chemotherapy in treatment of cervical cancer

Title:

The study drug pathomorphism and immunohistochemical parameters of tumor in endoarterial of regional long-term chemotherapy in treatment of cervical cancer
The study drug pathomorphism and immunohistochemical parameters of tumor in endoarterial of regional long-term chemotherapy in treatment of cervical cancer

Creator:

Navruzova, V. S. and Yuldasheva, N. Sh

Contributor:

Navruzova, V. S. and Yuldasheva, N. Sh

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc14045956-ff0c70da-4dc0-41b7-8ce5-68e736b8fddf
uuid:bmc14045956-ff0c70da-4dc0-41b7-8ce5-68e736b8fddf
local:bmc14045956
http://ojs.journals.cz/index.php/EMHPJ/issue/archive
local: bmc14045956

Subject:

nádory děložního čípku--patologie--terapie, imunohistochemie, staging nádorů, biopsie, metastázy nádorů, chemoterapie adjuvantní, radioterapie, nádorový supresorový protein p53--metabolismus, výsledek terapie, and lidé

Type:

model:article, article, Text, statistics, and TEXT

Format:

braille, electronic resource, remote, and elektronický zdroj

Description:

To improve the results of radiotherapy for cervical cancer used local and systemic radiomodification drugs. Materials and methods: 1984 patients with locally advanced cervical cancer (2b 3a stage), which at one stage of complex treatment by a course indoarterial of regional longterm polychemotherapy (EARDPHT) mode: methotrexate 50 mg/m2, the first 12 hours, fluorouracil 1000 mg/m2, over the next 12 hours and cisplatin 100 mg/m2, for 48 hours, 2 stage surgical treatment in the volume expanding hysterectomy 3 type (modification of Wertheim Meigs). Results: The results of treatment of locally cervical cancer using VADRPHT, depending on the unilateral and bilateral tumor invasion in parametrial tissue showed that under unilateral lesion of parametrium results of treatment were higher than for the bilateral involvement of parametrium. Medical pathomorphosis in tumors of different severity was observed in 86.9% of patients, metastasis to regional lymph nodes were detected in 36% of operated patients, and also studied the degree of therapeutic pathomorphosis in lymph nodes. There was revealed that the complete regression of tumors, 5 year survival rate is 98%, whereas in tumor regression of more than 50% of the original volume – 78.5%, with stabilization of tumor no more than 58.4%. Conclusion: The study of molecularbiological parameters of the tumor cells show the effectiveness of conducted neoadvent indoarterial chemotherapy and play an important role in further treatment and prediction of disease., Navruzova V. S., Yuldasheva N. Sh., and Literatura

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

European medical, health and pharmaceutical journal--MED00177703

Source:

European medical, health and pharmaceutical journal : open access reviewed journal | 2010 Volume:2010 | Number:1

Harvested from:

CDK

Metadata only:

false

Date:

2010