Preliminary study results of multiple drug resistance in patients with advanced types of colorectal cancer

Title:

Preliminary study results of multiple drug resistance in patients with advanced types of colorectal cancer
Preliminary study results of multiple drug resistance in patients with advanced types of colorectal cancer

Creator:

Navruzov, S. N., Abdujapparov, S. B., Pulatov, D. A., Islamov, H. D., Matniyazova, Sh. Ya, and Akbarov, E. T.

Contributor:

Navruzov, S. N., Abdujapparov, S. B., Pulatov, D. A., Islamov, H. D., Matniyazova, Sh. Ya, and Akbarov, E. T.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc14045955-37250a6e-358a-4b07-ab6e-e47f6d73231b
uuid:bmc14045955-37250a6e-358a-4b07-ab6e-e47f6d73231b
local:bmc14045955
http://ojs.journals.cz/index.php/EMHPJ/issue/archive
local: bmc14045955

Subject:

léková rezistence, nádory rekta--terapie, protokoly antitumorózní kombinované chemoterapie, staging nádorů, výsledek terapie, dospělí, staří, ženské pohlaví, lidé, mužské pohlaví, and lidé středního věku

Type:

model:article, article, Text, statistics, and TEXT

Format:

braille, electronic resource, remote, and elektronický zdroj

Description:

In the department of coloproctology of NORC MH RUz 17 patients with disseminated forms of colorectal cancer was made the study of oncogenes and complex treatment by 2 protocols using FOLFOX4 regime and FOLFIRI regime. In second protocol there used 2 sessions of endolymphatical polychemotherapy FOLFOX4 regime against EHFhyperthermia. All patients were performed additional investigations directed to study the presence of multiple drug resistance in them where definition of р53, bcl2 oncogene expression. In our observations we followed resistance to FOLFOX4 scheme in 4 patients, and to FOLFIRI scheme in 2 cases. In our studies hyperexpression of oncoproteine р53 was correlated with the effect of conducted therapy whereas hyperexpr, Navruzov S. N., Abdujapparov S. B., Pulatov D. A., Islamov H. D., Matniyazova Sh. Ya., Akbarov E. T., and Literatura

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

European medical, health and pharmaceutical journal--MED00177703

Source:

European medical, health and pharmaceutical journal : open access reviewed journal | 2010 Volume:2010 | Number:1

Harvested from:

CDK

Metadata only:

false

Date:

2010