Therapeutic erythrocytapheresis in the initial treatment of hereditary hemochromatosis

Title:

Therapeutic erythrocytapheresis in the initial treatment of hereditary hemochromatosis
Therapeutic erythrocytapheresis in the initial treatment of hereditary hemochromatosis

Creator:

Řeháček, Vít, Bláha, Milan, Jiroušová, Hana, Černohorská, Jitka, and Papoušek, Petr

Contributor:

Řeháček, Vít, Bláha, Milan , 1938-, Jiroušová, Hana, Černohorská, Jitka, and Papoušek, Petr

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc13037648-df785828-a86c-4eb8-8d7d-08a357701e57
uuid:bmc13037648-df785828-a86c-4eb8-8d7d-08a357701e57
local:bmc13037648
https://www.lfhk.cuni.cz/Faculty/Publications/Acta-Medica/Archive/
local: bmc13037648

Subject:

dospělí, staří, krevní složky - separace, transfuze erytrocytů, erytrocyty - objem, ženské pohlaví, hematokrit, hemochromatóza--krev--genetika--terapie, lidé, železo--krev, mužské pohlaví, lidé středního věku, and transferin--analýza

Type:

model:article, article, Text, časopisecké články, and TEXT

Format:

print, text, and regular print

Description:

BACKGROUND: The current treatment of hereditary hemochromatosis (HH) consists of performing periodic whole blood phlebotomies. Erythrocytapheresis (EA) can remove up to three times more red blood cells per single procedure and could thus have a clinical benefit. A prospective study of 30 consecutive cases of HH were included in a periodic EA program. METHODS AND PATIENTS: EA were performed using a discontinuous flow cell separators. The protocol consisted of a bimonthly EA until normalization of the serum ferritin was reached. The aim was to reduce the total erythrocyte volume by 25-35%, eventually, to adjust the amount so that hematocrit would not drop below 0.25. RESULTS: 530 +/- 101 ml of erythrocytes were removed (median 517, range 116-761 ml). Iron depletion (ferritin < 20 microg/l) was achieved in all patients after a mean 6.9 +/- 7.6 months, median 5 months, range 1-36 months and a mean 14 EA sessions. The procedures were well tolerated and there were no severe side-effects. CONCLUSIONS: We conclude that HH patients treated with EA achieved iron depletion quickly under good conditions of tolerance. The efficacy, speed, tolerability, and more favorable schedule of an EA program facilitate treatment of HH. and V. Rehácek, M. Bláha, H. Jirousová, J. Cernohorská, P. Papousek

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové--MED00010947

Source:

Acta medica (Hradec Králové) | 2012 Volume:55 | Number:4

Harvested from:

CDK

Metadata only:

false

Date:

2012