Genome-wide association studies in schizophrenia, and potential etiological and functional implications of their results

Title:

Genome-wide association studies in schizophrenia, and potential etiological and functional implications of their results
Genome-wide association studies in schizophrenia, and potential etiological and functional implications of their results

Creator:

Hosák, Ladislav, Šilhan, Petr, and Hosáková, Jiřina

Contributor:

Hosák, Ladislav , 1962-, Šilhan, Petr, and Hosáková, Jiřina

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc12016993-9c6c8db9-13a0-40b8-88d4-0a0cf86d2cb6
uuid:bmc12016993-9c6c8db9-13a0-40b8-88d4-0a0cf86d2cb6
local:bmc12016993
http://www.lfhk.cuni.cz/Data/files/Casopisy/2012/2012_3.pdf
local: bmc12016993

Subject:

srovnávací asociační studie genomů, lidé, and schizofrenie--genetika

Type:

model:article, article, Text, statistics, tabulky, přehledy, and TEXT

Format:

braille, electronic resource, remote, and elektronický zdroj

Description:

Background: Despite the fact that the genetic basis of schizophrenia has been intensively studied for more than two decades, our contemporary knowledge in this field is rather fractional, and a substantial part of it is still missing. The aim of this review article is to sum up the data coming from genome‑wide association genetic studies in schizophrenia, and indicate prospective directions of further scientific endeavour. Methods: We searched the National Human Genome Research Institute’s Catalog of genome‑wide association studies for schizophrenia to identify all papers related to this topic. In consequence, we looked up the possible relevancy of these findings for etiology and pathogenesis of schizophrenia using the computer gene and PubMed databases. Results: Eighteen genome‑wide association studies in schizophrenia have been published till now, referring to fifty‑seven genes supposedly involved into schizophrenia’s etiopathogenesis. Most of these genes are related to neurodevelopment, neuroendocrinology, and immunology. Conclusions: It is reasonable to predict that complex studies of sufficiently large samples, involving detection of copy number variants and assessment of endophenotypes, will produce definitive discoveries of genetic risk factors for schizophrenia in the future., Ladislav Hosák, Petr Šilhan, Jiřina Hosáková, and Literatura 48

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové)--MED00010947

Source:

Acta medica (Hradec Králové) | 2012 Volume:55 | Number:1

Harvested from:

CDK

Metadata only:

false

Date:

2012