Stiff-person syndrome following tick-borne meningoencephalitis

Title:

Stiff-person syndrome following tick-borne meningoencephalitis
Stiff-person syndrome following tick-borne meningoencephalitis

Creator:

Ehler, Edvard, Latta, Ján, Mandysová, Petra, Havlasová, Jana, and Mrklovský, Milan

Contributor:

Ehler, Edvard, Latta, Ján, Mandysová, Petra, Havlasová, Jana, and Mrklovský, Milan

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc12000870-7cbbbf49-60df-48bb-bdf2-b1ee3c59b90b
uuid:bmc12000870-7cbbbf49-60df-48bb-bdf2-b1ee3c59b90b
local:bmc12000870
http://www.lfhk.cuni.cz/Data/files/Casopisy/2011/2011_170.pdf
local: bmc12000870

Subject:

elektromyografie, klíšťová encefalitida--diagnóza--komplikace, lidé, magnetická rezonanční tomografie, mužské pohlaví, meningoencefalitida--komplikace, lidé středního věku, and syndrom celkového ztuhnutí--diagnóza--etiologie--farmakoterapie

Type:

model:article, article, Text, kazuistiky, and TEXT

Format:

braille, text, and regular print

Description:

Stiff-person syndrome (SPS) is a rare disorder characterized by muscle stiffness and painful spasms. Misdiagnosis may occur due to the fact that the clinical picture of SPS is often atypical. The main pathophysiologic mechanism underlying the development of SPS is insufficient inhibition at the cortical and spinal levels. There is good evidence for a primary autoimmune etiology. A 61-year-old man was admitted to a neurological department due to muscle hypertonia with episodic attacks of painful spasms predominantly affecting axial muscles. The symptoms developed shortly after tickborne meningoencephalitis. Electromyography (EMG) revealed signs of continuous motor unit activity. Antibodies against glutamate decarboxylase (anti-GAD) were highly elevated. We present a case of a man who developed clinically severe anti-GAD positive SPS, provoked by tick-borne encephalitis. After therapeutic plasma exchange (TPE) a rapid, temporary improvement of the clinical and neurophysiological findings was noted. Only after being placed on long-term immunosuppression did the patient achieve stable recovery. This case supports the importance of EMG findings and demonstrates the effect of TPE as well as the need for chronic immunosuppression in severe cases of SPS., Edvard Ehler, Jan Latta, Petra Mandysová, Jana Havlasová, Milan Mrklovský, and Literatura 22

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové)--MED00010947

Source:

Acta medica (Hradec Králové) | 2011 Volume:54 | Number:4

Harvested from:

CDK

Metadata only:

false

Date:

2011