Effects of histamine H1 antagonist dithiaden on acetic acid-induced colitis in rats

Title:

Effects of histamine H1 antagonist dithiaden on acetic acid-induced colitis in rats

Creator:

Viera Nosáľová, Oľga Ondrejičková, and Jana Pečivová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bf3b8e8f-db3b-465b-9e44-330277f5f0e3
uuid:bf3b8e8f-db3b-465b-9e44-330277f5f0e3
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, histamin, histamine, dithiaden, acetic acid-induced colitis, mast cells, rats, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

To assess the possible involvement of mast cells and/or their mediators in inflammatory bowel diseases, the effect of the histamine H1 antagonist Dithiaden was studied on a model of acetic acid-induced colitis in rats. Dithiaden pretreatment by intracolonic administration was found to reduce the extent of acute inflammatory colonic injury. This was manifested by a decrease in the score of gross mucosal injury, by lowered colonic wet weight and by diminished myeloperoxidase activity reflecting reduced leukocyte infiltration. Vascular permeability and gamma-glutamyl transpeptidase activity, elevated by acetic acid exposure, were decreased after Dithiaden pretreatment. The results indicate that locally administered Dithiaden may protect the colonic mucosa against an acute inflammatory attack by interfering with the action of the major mast cell mediator histamine., V. Nosáľová, O. Ondrejičková, J. Pečivová., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1999 Volume:48 | Number:1

Harvested from:

CDK

Metadata only:

false